Results 81 to 90 of about 14,275 (206)

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT

mSphere
The eukaryotic CCR4−NOT deadenylase complex is a highly conserved regulator of mRNA metabolism that influences the expression of the complete transcriptome, representing a prime target for a generalist bacterial pathogen.
Harley O'Connor Mount, Malene L. Urbanus, Francesco Zangari, Anne-Claude Gingras, Alexander W. Ensminger   +4 more
doaj   +1 more source

The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation

Life Science Alliance, 2020
The CCR4–NOT complex maintains liver homeostasis by fine-tuning levels of mRNAs, including those for transcription factors, cell cycle regulators, DNA damage response proteins, and liver function–related molecules.
Akinori Takahashi, Toru Suzuki, Shou Soeda, Shohei Takaoka, Shungo Kobori, Tomokazu Yamaguchi, Haytham Mohamed Aly Mohamed, Akiko Yanagiya, Takaya Abe, Mayo Shigeta, Yasuhide Furuta, Keiji Kuba, Tadashi Yamamoto   +12 more
doaj   +1 more source

Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]

, 2008
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan, Erica Hennessy, Lorraine O'Driscoll, Offield, Schleicher, Zhou   +5 more
core   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Deadenylation is a widespread effect of miRNA regulation [PDF]

RNA, 2008
miRNAs silence gene expression by repressing translation and/or by promoting mRNA decay. In animal cells, degradation of partially complementary miRNA targets occurs via deadenylation by the CAF1-CCR4-NOT1 deadenylase complex, followed by decapping and subsequent exonucleolytic digestion.
Eulalio, A., Huntzinger, E., Nishihara, T., Rehwinkel, J., Fauser, M., Izaurralde, E.   +5 more
openaire   +3 more sources

Specificity factors in cytoplasmic polyadenylation [PDF]

, 2013
Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development.
Afonina, Alarcon, Andres-Aguayo, Arumugam, Ascano, Aslam, Atkins, Atkins, Baines, Balagopal, Ballantyne, Bardwell, Barkoff, Barkoff, Barnard, Barnard, Bazzini, Belloc, Belloc, Benoit, Berger-Sweeney, Bermudez, Berndt, Bestman, Bestman, Bethune, Bilger, Bouvet, Bouvrette, Bouvrette, Brawerman, Brook, Brook, Burgess, Burgess, Burns, Burns, Bushell, Campbell, Campbell, Cao, Cao, Cao, Castagnetti, Cervello, Chan, Chang, Charlesworth, Charlesworth, Charlesworth, Charlesworth, Charlesworth, Chen, Chen, Chen, Cheng, Cheng, Chicoine, Choi, Clarke, Cogswell, Coll, Collier, Cooke, Costa, Craig, Darnell, Darnell, Dasgupta, De Moor, De Moor, Derry, Dettwiler, Di Giammartino, Dickson, Dickson, Didiot, Djuranovic, Du, Eckmann, Eckmann, Edwards, Eiring, Eliscovich, Ernoult-Lange, Ezeh, Fabian, Fan, Ferby, Fernandez-Miranda, Fox, Frank-Vaillant, Friend, Fu, Gavin, Gebauer, Gebauer, Gonzales, Gravina, Groisman, Groisman, Groisman, Groisman, Gunter, Guzeloglu-Kayisli, Guzeloglu-Kayisli, Hafer, Hake, Hake, Hodgman, Hoog, Hosoda, Hosoda, Houseley, Hu, Huang, Huang, Huang, Huarte, Hägele, Igea, Imai, Jenkins, Ji, Jin, Johnson, Jones, Juge, Kan, Kashiwabara, Kashiwabara, Kashiwabara, Katoh, Kaufmann, Kawahara, Keady, Keleman, Kerwitz, Kiessling, Kim, Kim, Kim, Kim, Kim, Kojima, Kolev, Kondrashov, Kosaka, Kraus, Kruttner, Kuehn, Kuehner, Kuhn, Kundel, Kuo, Kuo, Kwak, Kwak, Laishram, Laishram, Lee, Li, Lin, Lin, Luitjens, Lutz, Ma, Maisonneuve, Makeyev, Mandel, Martin, Martineau, Martinez, Martinson, Masuda, Maton, McEvoy, McGrew, McGrew, McPheeters, Meijer, Meijer, Meijer, Mellman, Mellman, Mendez, Mendez, Mendez, Menon, Millevoi, Moore, Moretti, Mukherjee, Nagaike, Nagaoka, Nairismagi, Nakahata, Nakahata, Nakahata, Nakanishi, Nakanishi, Nakel, Novoa, Okano, Oruganty-Das, Osborne, Ostareck-Lederer, Padmanabhan, Paffenholz, Paillard, Paillard, Papin, Paris, Paris, Pavlopoulos, Pederson, Peng, Piazzon, Pique, Preker, Proudfoot, Qu, Quenault, Racki, Radford, Rattenbacher, Reverte, Reverte, Reynolds, Roretz, Rouhana, Ryan, Rybarska, Sagata, Sagawa, Sakakibara, Sallés, Sasayama, Schmid, Schoenberg, Seli, Setoyama, Shcherbik, Sheets, Sheets, Shi, Shinojima, Si, Si, Si, Simon, Simon, Simon, Slevin, Soucek, Standart, Stebbins-Boaz, Suh, Suh, Suzuki, Takagaki, Takeda, Tan, Tay, Tay, Tay, Teplova, Theis, Tian, Todaro, Topalian, Tran, Tucker, Udagawa, van, Vardy, Vassalli, Vessey, Villalba, Vishnu, Vogler, Wang, Wang, Wang, Wang, Wang, Watanabe, Weill, Weiss, Wells, Wilt, Wiszniak, Wong, Wong, Wong, Wreden, Wu, Wu, Wu, Wu, Yang, Yang, Yang, Ye, Yen, Yeo, Zalfa, Zearfoss, Zeng, Zhao, Zhong, Zhuang   +311 more
core   +2 more sources

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Deadenylation-independent stage-specific mRNA degradation in Leishmania [PDF]

Nucleic Acids Research, 2008
The life cycle of Leishmania alternates between developmental forms residing within the insect vector (e.g. promastigotes) and the mammalian host (amastigotes). In Leishmania nearly all control of gene expression is post-transcriptional and involves sequences in the 3'-untranslated regions (3'UTRs) of mRNAs.
Haile, Simon, Dupé, Aurélien, Papadopoulou, Barbara   +2 more
openaire   +2 more sources

Post-transcriptional regulation in Xenopus embryos: role and targets of EDEN-BP. [PDF]

, 2005
International audienceEDEN (embryo deadenylation element)-dependent deadenylation is a regulatory process that was initially identified in Xenopus laevis early embryos and was subsequently shown to exist in Drosophila oocytes.
Audic, Yann, Barreau, Carine, Gautier-Courteille, Carole, Graindorge, Antoine, Osborne, Howard Beverley, Paillard, Luc, Pollet, Nicolas, Thuret, Raphaël   +7 more
core   +3 more sources