Results 81 to 90 of about 9,376 (189)

The CAF1-NOT complex of trypanosomes

Frontiers in Genetics, 2014
In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans splicing and polyadenylation.
Esteban eErben, Chaitali eChakraborty, Christine eClayton   +2 more
doaj   +1 more source

The N6‐methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma

Clinical and Translational Medicine, 2022
Background Solute carrier family 7 member 11 (SLC7A11) is overexpressed in multiple human tumours and functions as a transporter importing cystine for glutathione biosynthesis.
Li Liu, Jiangtu He, Guifeng Sun, Nan Huang, Zhixuan Bian, Chang Xu, Yue Zhang, Zhongqi Cui, Wenqiang Xu, Fenyong Sun, Chengle Zhuang, Qiuhong Man, Song Gu   +12 more
doaj   +1 more source

Transcriptomic Convergence in Autism Spectrum Disorder: Synaptic, Immune‐Glial and RNA‐Regulatory Axes in the Human Cerebral Cortex

International Journal of Developmental Neuroscience, Volume 86, Issue 5, August 2026.
Across 43 human post‐mortem cortical transcriptomic studies, ASD shows recurrent but non‐uniform convergence on reduced synaptic‐neuronal signalling, increased immune‐glial activity and RNA‐regulatory dysregulation. Metabolic and mitochondrial changes are less consistently supported and appear more conditional within the current cortical evidence base.
Ruslan Kurmashev
wiley   +1 more source

Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex

, 2023
Deadenylation generally constitutes the first and pivotal step in eukaryotic messenger RNA decay. Despite its importance in posttranscriptional regulations, the kinetics of deadenylation and its regulation remain largely unexplored.
Park, Joha, Myeonghwan Kim, Choi, Yongkuk, Kim, V. Narry, Hyerim Yi, V. Narry Kim, Yi, Hyerim, Young-suk Lee, Baeg, Kyungmin, Lee, Young-suk, Joha Park, Jaechul Lim, Lim, Jaechul, Kyungmin Baeg, Kim, Myeonghwan, Yongkuk Choi   +15 more
core   +1 more source

AID‐Mediated Protein Knockdown Reveals the Requirement of NANOS2 in Prenatal Gonocytes for Establishing Functional Spermatogonial Stem Cells

Development, Growth &Differentiation, Volume 68, Issue 6, August 2026.
ABSTRACT The RNA‐binding protein NANOS2 plays a crucial role in male gonocyte development and the maintenance of spermatogonial stem cells. In the absence of the Nanos2 gene (Nanos2‐KO), germ cells fail to enter G0 arrest and initiate the male differentiation program (including DNA methylation and the piRNA pathway), ultimately undergoing apoptosis ...
Yumiko Saga, Quan Wu
wiley   +1 more source

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation [PDF]

, 2009
MicroRNAs (miRNAs) inhibit mRNA expression in general by base pairing to the 3′UTR of target mRNAs and consequently inhibiting translation and/or initiating poly(A) tail deadenylation and mRNA destabilization.
Wohlschlegel, J., Filipowicz, Witold, Fabian, M. R., Sundermeier, Thomas, Svitkin, Yuri V, Duchaine, Thomas F, Duchaine, T. F., Hannon, Gregory J, Jinek, M., Yates, John R, Svitkin, Y. V., Rivas, F., Sundermeier, T., Yates Iii, J. R., Mathonnet, Géraldine, Sonenberg, Nahum, Hannon, G. J., Fabian, Marc R, Doudna, Jennifer A, Wohlschlegel, James, Zipprich, Jakob T, Filipowicz, W., Jinek, Martin, Chen, Chyi-Ying A, Mathys, Hansruedi, Zipprich, J. T., Doudna, J. A., Shyu, Ann-Bin, Mathys, H., Rivas, Fabiola, Shyu, A. B., Mathonnet, G., Chen, C. Y. A., Sonenberg, N.   +33 more
core   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, Volume 13, Issue 37, 3 July 2026.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Novel roles of the multifunctional CCR4-NOT complex in post-transcriptional regulation

Frontiers in Genetics, 2014
The CCR4-NOT complex is highly conserved gene silencer, and more general functions of the complex have been elucidated at post-transcriptional levels. Specific regulatory proteins, including miRNA-induced silencing complex and its associate protein, bind
Toshifumi eInada, Shiho eMakino
doaj   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, Volume 255, Issue 7, Page 628-645, July 2026.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Inhibition of tristetraprolin deadenylation by poly(A) binding protein

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2008
Tristetraprolin (TTP) is the prototype for a family of RNA binding proteins that bind the tumor necrosis factor (TNF) messenger RNA AU-rich element (ARE), causing deadenylation of the TNF poly(A) tail, RNA decay, and silencing of TNF protein production. Using mass spectrometry sequencing we identified poly(A) binding proteins-1 and -4 (PABP1 and PABP4)
Robert M, Rowlett, Carol A, Chrestensen, Melanie J, Schroeder, Mary G, Harp, Jared W, Pelo, Jeffery, Shabanowitz, Robert, DeRose, Donald F, Hunt, Thomas W, Sturgill, Mark T, Worthington   +9 more
openaire   +3 more sources