Results 131 to 140 of about 14,275 (206)

The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay. [PDF]

, 2018
The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA levels are determined through its
Begley, Victoria Sarah
core  

Most \u3cem\u3eCaenorhabditis elegans\u3c/em\u3e MicroRNAs are Individually Not Essential for Development or Viability [PDF]

, 2007
MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding
Abbott, Allison L., Alvarez-Saavedra, Ezequiel, Ambros, Victor R., Bartel, David P., Hellman, Andrew B., Horvitz, H. Robert, Lau, Nelson C., McGonagle, Shannon M., Miska, Eric A.   +8 more
core   +1 more source

A knock-in tristetraprolin (TTP) zinc finger point mutation in mice: Comparison with complete TTP deficiency [PDF]

, 2018
Blackshear, Perry J, Faccio, Roberta, Lai, Wi S, Qiu, Lianqun, Stumpo, Deborah J   +4 more
core   +2 more sources

Mechanisms governing poly(A)-tail-length specificity of the human PAN2-PAN3 deadenylase complex

Cell Reports
Summary: The lifespan of most eukaryotic mRNAs is modulated by the gradual shortening of the poly(A) tail and removal of the associated poly(A)-binding protein.
Jana C. Albrecht, Timo Reitinger, Jérôme Basquin, Steffen Schüssler, Margot Riggi, Ingmar B. Schäfer, Elena Conti   +6 more
doaj   +1 more source

Phosphorylation-dependent tuning of mRNA deadenylation rates. [PDF]

Nat Struct Mol Biol
Stowell JAW, Yu CWH, Chen ZA, DeBell LK, Lee GC, Morgan T, Sinn L, Agnello S, O'Reilly FJ, Rappsilber J, Freund SMV, Passmore LA.   +11 more
europepmc   +2 more sources

Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes

Journal of Inflammation Research
Tomokazu Yamaguchi,1,2,* Ryo Ozawa,2,3,* Takafumi Minato,2 Midori Hoshizaki,4 Yutaro Kammura,1,5 Kazuma Okawara,1,6 Yousef A Khalil,1 Masafumi Nakamura,6 Ken Yamaura,5 Masayuki Fukuda,3 Yumiko Imai,4 Keiji Kuba1,2 1Department of Pharmacology ...
Yamaguchi T, Ozawa R, Minato T, Hoshizaki M, Kammura Y, Okawara K, Khalil YA, Nakamura M, Yamaura K, Fukuda M, Imai Y, Kuba K   +11 more
doaj  

Author Correction: Phosphorylation-dependent tuning of mRNA deadenylation rates. [PDF]

Nat Struct Mol Biol
Stowell JAW, Yu CWH, Chen ZA, DeBell LK, Lee GC, Morgan T, Sinn L, Agnello S, O'Reilly FJ, Rappsilber J, Freund SMV, Passmore LA.   +11 more
europepmc   +1 more source

Poly(A) tail regulation in stem cells and early development. [PDF]

Cell Regen
Miao X, Hu G.
europepmc   +1 more source

The CCR4-NOT complex: a multifaceted sensor of molecular signals instructing eukaryotic mRNA translation and stability. [PDF]

Nucleic Acids Res
Caulier G, Siblini J, Sène L, Mauxion F, Séraphin B.   +4 more
europepmc   +1 more source

Plant P-bodies in post-transcriptional control: Composition, dynamics, and context-dependent roles. [PDF]

Plant Commun
Matinahmadi A, Zayani Z, Majewska K, Smoliński DJ.   +3 more
europepmc   +1 more source