Results 151 to 160 of about 9,376 (189)
Regulation of mRNA poly(A) tail length governs mammalian body plan formation in gastruloids. [PDF]
Nat CommunTaborsky D +19 more
europepmc +1 more source
Cytoplasmic mRNA decay and quality control machineries in eukaryotes. [PDF]
Nat Rev GenetDowdle ME, Lykke-Andersen J.
europepmc +1 more source
The CCR4-NOT deadenylase complex mediates tubulin autoregulation <i>via</i> specific adapters CNOT10 and CNOT11. [PDF]
MicroPubl BiolSarbanes SL, Hogg JR, Roll-Mecak A.
europepmc +1 more source
Poly(A) tail degradation in human cells: ATF4 mRNA as a model for biphasic deadenylation
Biochimie, 2021 International audienceEukaryotic mRNA deadenylation is generally considered as a two-step process in which the PAN2-PAN3 complex initiates the poly(A) tail degradation while, in the second step, the CCR4-NOT complex completes deadenylation, leading to ...
Olivier Jean-Jean
exaly +2 more sources
Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding
Biology of the Cell, 2006 International audienceBACKGROUND INFORMATION: mRNA deadenylation [shortening of the poly(A) tail] is often triggered by specific sequence elements present within mRNA 3' untranslated regions and generally causes rapid degradation of the mRNA.
Carole Gautier-Courteille +2 more
exaly +2 more sources
PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay
Molecular Cell, 2018 Multiple deadenylases are known in vertebrates, the PAN2-PAN3 (PAN2/3) and CCR4-NOT (CNOT) complexes, and PARN, yet their differential functions remain ambiguous. Moreover, the role of poly(A) binding protein (PABP) is obscure, limiting our understanding
Joha Park, Vic Narry Kim, Jaechul Lim
exaly +3 more sources
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Science, 2020
Immunology When cells are quiescent, they undergo reversible cell cycle arrest and evince low basal metabolism. Naive T cells are normally quiescent until they recognize cognate antigens through T cell receptor–costimulatory molecule signaling. T cell quiescence appears to be an active process, but the mechanistic details are poorly understood.
openaire +1 more source
Immunology When cells are quiescent, they undergo reversible cell cycle arrest and evince low basal metabolism. Naive T cells are normally quiescent until they recognize cognate antigens through T cell receptor–costimulatory molecule signaling. T cell quiescence appears to be an active process, but the mechanistic details are poorly understood.
openaire +1 more source
Assaying mRNA Deadenylation In Vivo
2014Deadenylation is the removal of poly(A) tails from mRNA. Here, we present two methods for assaying deadenylation in vivo. The first is a method for measuring bulk poly(A) tail lengths. When combined with a block in transcription, the method can be used for measuring the rate of bulk poly(A) tail shortening.
Claudia, Temme, Elmar, Wahle
openaire +2 more sources