Results 131 to 140 of about 14,150 (193)

Molecular Pathogenesis of Preeclampsia: MicroRNA Hypothesis [PDF]

, 2011
The discovery of micro RNA (miRNA) in 1993 by Ambros and colleagues has a huge influence in pathogenesis theory, diagnosis and treatment approach of some diseases.
Andalas, M. (Mohd), Harapan, H. (H), Ichsan, M. (Muhammad), Laddha, S. (Saurabh), Mudhakir, D. (Diky), Pedroza, N. C. (Natalia)   +5 more
core   +1 more source

The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)

Nature Communications, 2019
Nocturnin is a rhythmically expressed protein that regulates metabolism under the control of circadian clock proposed to function through the deadenylation of metabolic enzyme mRNAs.
Michael A. Estrella, Jin Du, Li Chen, Sneha Rath, Eliza Prangley, Alisha Chitrakar, Tsutomu Aoki, Paul Schedl, Joshua Rabinowitz, Alexei Korennykh   +9 more
doaj   +1 more source

Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]

, 2013
MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core  

The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression [PDF]

, 2017
The control of messenger RNA (mRNA) function by micro RNAs (miRNAs) in animal cells requires the GW182 protein. GW182 is recruited to the miRNA repression complex via interaction with Argonaute protein, and functions downstream to repress protein ...
Chekulaeva, Marina, Filipowicz, Witold, Parker, Roy   +2 more
core  

Mechanisms governing poly(A)-tail-length specificity of the human PAN2-PAN3 deadenylase complex

Cell Reports
Summary: The lifespan of most eukaryotic mRNAs is modulated by the gradual shortening of the poly(A) tail and removal of the associated poly(A)-binding protein.
Jana C. Albrecht, Timo Reitinger, Jérôme Basquin, Steffen Schüssler, Margot Riggi, Ingmar B. Schäfer, Elena Conti   +6 more
doaj   +1 more source

A knock-in tristetraprolin (TTP) zinc finger point mutation in mice: Comparison with complete TTP deficiency [PDF]

, 2018
Blackshear, Perry J, Faccio, Roberta, Lai, Wi S, Qiu, Lianqun, Stumpo, Deborah J   +4 more
core   +2 more sources

Phosphorylation-dependent tuning of mRNA deadenylation rates. [PDF]

Nat Struct Mol Biol
Stowell JAW, Yu CWH, Chen ZA, DeBell LK, Lee GC, Morgan T, Sinn L, Agnello S, O'Reilly FJ, Rappsilber J, Freund SMV, Passmore LA.   +11 more
europepmc   +2 more sources

Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes

Journal of Inflammation Research
Tomokazu Yamaguchi,1,2,* Ryo Ozawa,2,3,* Takafumi Minato,2 Midori Hoshizaki,4 Yutaro Kammura,1,5 Kazuma Okawara,1,6 Yousef A Khalil,1 Masafumi Nakamura,6 Ken Yamaura,5 Masayuki Fukuda,3 Yumiko Imai,4 Keiji Kuba1,2 1Department of Pharmacology ...
Yamaguchi T, Ozawa R, Minato T, Hoshizaki M, Kammura Y, Okawara K, Khalil YA, Nakamura M, Yamaura K, Fukuda M, Imai Y, Kuba K   +11 more
doaj  

Poly(A) tail regulation in stem cells and early development. [PDF]

Cell Regen
Miao X, Hu G.
europepmc   +1 more source

The CCR4-NOT complex: a multifaceted sensor of molecular signals instructing eukaryotic mRNA translation and stability. [PDF]

Nucleic Acids Res
Caulier G, Siblini J, Sène L, Mauxion F, Séraphin B.   +4 more
europepmc   +1 more source