Results 11 to 20 of about 14,150 (193)
CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State
Stem Cell Reports, 2016 Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood.
Xiaofeng Zheng +13 more
doaj +3 more sources
A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C. [PDF]
, 2015 The regulation of protein and mRNA turnover is essential for many cellular processes. We recently showed that ubiquitin--traditionally linked to protein degradation--directly regulates the degradation of mRNAs through the action of a newly identified ...
Cano, Florencia +3 more
core +23 more sources
RNF219 RING Finger Domain Mutants Drive Phase Separation to Encapsulate CCR4-NOT and Promote Cell Proliferation. [PDF]
Cell ProlifMutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen C, Guo C, Fang K, Lin C, Luo Z.
europepmc +2 more sources
microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. [PDF]
PLoS ONE, 2009 Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially complementary target sites in the 3' untranslated region (UTR) of messenger RNA (mRNA) reducing its translation and stability.
Traude H Beilharz +6 more
doaj +1 more source
mRNA deadenylation by Pan2–Pan3 [PDF]
Biochemical Society Transactions, 2014 Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3′→5′ exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylation activity in eukaryotes: Ccr4–Not and Pan2–Pan3.
Wolf J, Passmore LA.
openaire +2 more sources
mRNA deadenylation and telomere disease [PDF]
Journal of Clinical Investigation, 2015 Dyskeratosis congenita (DC) is an inherited BM failure disorder that is associated with mutations in genes involved with telomere function and maintenance; however, the genetic cause of many instances of DC remains uncharacterized. In this issue of the JCI, Tummala and colleagues identify mutations in the gene encoding the poly(A)-specific ribonuclease
Philip J, Mason, Monica, Bessler
openaire +3 more sources
Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. [PDF]
PLoS ONE, 2012 Nanos is one of the evolutionarily conserved proteins implicated in germ cell development and we have previously shown that it interacts with the CCR4-NOT deadenylation complex leading to the suppression of specific RNAs. However, the molecular mechanism
Atsushi Suzuki +4 more
doaj +1 more source
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex
Frontiers in Cell and Developmental Biology, 2023 Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Lorenzo Pavanello +2 more
doaj +1 more source
Mechanisms of deadenylation‐dependent decay [PDF]
WIREs RNA, 2010 AbstractDegradation of messenger RNAs (mRNAs) plays an essential role in modulation of gene expression and in quality control of mRNA biogenesis. Nearly all major mRNA decay pathways characterized thus far in eukaryotes are initiated by deadenylation, i.e., shortening of the mRNA 3′ poly(A) tail.
Chyi-Ying A, Chen, Ann-Bin, Shyu
openaire +2 more sources
The Regulatory Properties of the Ccr4–Not Complex
Cells, 2020 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim, Roger J. Grand
doaj +1 more source