Results 31 to 40 of about 14,150 (193)
Identification of novel post-transcriptional features in olfactory receptor family mRNAs. [PDF]
, 2015 Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance in olfaction, how most Olfr mRNAs are regulated remains unexplored.
Espinoza, Josh L +3 more
core +1 more source
RNA deadenylation complexes in development and diseases
Biochemistry and Cell Biology, 2023 RNA deadenylation, the process of shortening of the 3′ poly(A) tail of an RNA molecule, is one of the key steps of post-transcriptional regulation of gene expression in eukaryotic cells. PAN2/3 and CCR4-NOT (CNOT) are the two dominant RNA deadenylation complexes, which play central roles in mediating mRNA decay and translation.
Yilin Liu, Niveditha Ramkumar, Ly P. Vu
openaire +2 more sources
CUG-BP and 3'UTR sequences influence PARN-mediated deadenylation in mammalian cell extracts
Genetics and Molecular Biology, 2007 Several mRNAs have been shown to exhibit distinct patterns of poly(A) shortening prior to their decay in vivo. In this study, we show that individual transcripts also demonstrate distinct patterns of deadenylation in in vitro systems derived from HeLa ...
Karen C.M. Moraes +2 more
doaj +1 more source
SPT5 affects the rate of mRNA degradation and physically interacts with CCR4 but does not control mRNA deadenylation [PDF]
, 2011 The CCR4-NOT complex has been shown to have multiple roles in mRNA metabolism, including that of transcriptional elongation, mRNA transport, and nuclear exosome function, but the primary function of CCR4 and CAF1 is in the deadenylation and degradation ...
Chiang, Yueh-Chin +4 more
core +2 more sources
Embryo Deadenylation Element-Dependent Deadenylation Is Enhanced by a cis Element Containing AUU Repeats [PDF]
Molecular and Cellular Biology, 1998 The deadenylation of maternal mRNAs in the Xenopus embryo is a sequence-specific process. One cis element that targets maternal mRNAs for deadenylation after fertilization is the embryo deadenylation element (EDEN). This element, composed of U/R repeats, is specifically bound by a protein, EDEN-BP. In the present study we show that the rate at which an
Audic, Yann +2 more
openaire +2 more sources
Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding. [PDF]
, 2006 International audienceBACKGROUND INFORMATION: mRNA deadenylation [shortening of the poly(A) tail] is often triggered by specific sequence elements present within mRNA 3' untranslated regions and generally causes rapid degradation of the mRNA.
Aït-Ahmed, Ounissa +6 more
core +3 more sources
Cytoplasmic deadenylation: regulation of mRNA fate [PDF]
Biochemical Society Transactions, 2010 The poly(A) tail of mRNA has an important influence on the dynamics of gene expression. On one hand, it promotes enhanced mRNA stability to allow production of the protein, even after inactivation of transcription. On the other hand, shortening of the poly(A) tail (deadenylation) slows down translation of the mRNA, or prevents it entirely, by inducing ...
Katrin, Wiederhold, Lori A, Passmore
openaire +2 more sources
eLife, 2020 La-related protein 4 (LARP4) directly binds both poly(A) and poly(A)-binding protein (PABP). LARP4 was shown to promote poly(A) tail (PAT) lengthening and stabilization of individual mRNAs presumably by protection from deadenylation (Mattijssen et al ...
Sandy Mattijssen +4 more
doaj +1 more source
piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm [PDF]
, 2017 Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine ...
Beilharz, Traude H. +9 more
core +4 more sources
Targeted mRNA Degradation by Deadenylation-Independent Decapping [PDF]
Molecular Cell, 2004 Modulating the rate of mRNA degradation is a fast and efficient way to control gene expression. In a yeast strain deleted of EDC3, a component of the decapping machinery conserved in eukaryotes, the transcript coding the ribosomal protein Rps28b is specifically stabilized, as demonstrated by microarray and time course experiments.
Badis, Gwenaël +3 more
openaire +3 more sources