Results 51 to 60 of about 3,287 (284)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
PENGARUH DEFENSIVE SILENCE DAN STRES KERJA TERHADAP KOMITMEN AFEKTIF KARYAWAN DISPARBUD JEPARA DENGAN EFEK MODERASI GAYA KEPEMIMPINAN TRANSFORMATIONAL [PDF]
, 2015 Fenomena silence dalam organisasi ini perlu diwaspadai dan mendapatkan perhatian yang serius dari organisasi. Penelitian ini meneliti bagaimana pengaruh Defensive silence dan work stress terhadap komitmen afektif dengan efek moderasi gaya ...
WARDHANI, WINDI NOVIA RATRI
core
Disempowering defensive silence: The role of empowering leadership, sense of power, and dyadic tenure [PDF]
, 2020 Employees’ silence is a problem for organizations, but research has not sufficiently addressed this behavior, especially the hard-to-change emotion-based defensive silence.
Almeida, Santiago Barros de
core
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Conscious Decision to Engage in Defensive Silence: An Expectancy Theory Perspective [PDF]
International Review of Management and Business Research, 2020 The supervisor’s negative attitude towards voice and unavailability of communication channels are considered significant predictors of defensive silence. However, lesser consideration has been given to provide an in-depth explanation of how and why these motivational forces influence employees’ step by step conscious decision to engage in defensive ...
AMEN IMRAN +2 more
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji +13 more
wiley +1 more source
Effect of Organizational Silence on Employees’ Productivity [PDF]
International Journal of Management, Accounting and Economics, 2019 Productivity and development of any organization depends highly on the right application of human resources in the organization. One of the factors affecting productivity is organizational silence which has not been considered today.
Gholamreza Bordbar +3 more
doaj
Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells
Redox Biology, 2016 Nrf2 pathway has been known to be protective against cancer progression however recent studies have revealed that the antioxidant activity of Nrf2 contributes to chemotherapy resistance. For many years, hyperthermia has been used as an additional therapy to increase the efficiency of chemotherapy and radiotherapy.
Bozaykut, Perinur +2 more
openaire +5 more sources
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source