Results 31 to 40 of about 32,113 (291)

Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

Pharmaceutics, 2020
The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug.
M. Lazaridou, Evi Christodoulou, M. Nerantzaki, M. Kostoglou, D. Lambropoulou, A. Katsarou, K. Pantopoulos, D. Bikiaris   +7 more
semanticscholar   +1 more source

Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study

Blood Advances, 2021
Key Points The efficacy of deferiprone was noninferior to deferoxamine for treating transfusional iron overload in patients with SCD or other anemias. The safety profile of deferiprone in patients with SCD was tolerable and similar to previous reports in
J. Kwiatkowski, Mona Hamdy, Amal El Beshlawy, F. Ebeid, Mohammed Badr, Abdulrahman Ali M AlShehri, J. Kanter, B. Inusa, Amira Adly, S. Williams, Yurdanur Kilinc, David Lee, F. Tricta, MS Elalfy   +13 more
semanticscholar   +1 more source

Abrupt increased serum creatinine in a hyperferritinemia patient treated with deferoxamine after cord blood transplantation: a case report with literature review

Journal of Pharmaceutical Health Care and Sciences, 2023
Background Erythrocyte transfusion is an indispensable component of supportive care after hematopoietic stem cell transplantation (HSCT). However, HSCT recipients are susceptible to the development of acute kidney injury (AKI) with multifactorial causes.
Hirokazu Nakayama, Yoshimasa Kamoda, Michiya Tanuma, Toshiaki Kato, Kensuke Usuki   +4 more
doaj   +1 more source

UAMC-3203 or/and Deferoxamine Improve Post-Resuscitation Myocardial Dysfunction Through Suppressing Ferroptosis in a Rat Model of Cardiac Arrest

Shock, 2021
Blocking ferroptosis reduces ischemia-reperfusion injury in some pathological contexts. However, there is no evidence that ferroptosis contributes to post-resuscitation myocardial dysfunction (PRMD).
Tao Jin, Qing He, Cheng Cheng, Hui Li, Lian Liang, Guozhen Zhang, Chenglei Su, Yan Xiao, J. Bradley, M. Peberdy, J. Ornato, Wanchun Tang   +11 more
semanticscholar   +1 more source

Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors

Haematologica, 2016
Iron overload due to hemochromatosis or chronic blood transfusions has been associated with the development of osteoporosis. However, the impact of changes in iron homeostasis on osteoblast functions and the underlying mechanisms are poorly defined ...
Ulrike Baschant, Martina Rauner, Ekaterina Balaian, Heike Weidner, Antonella Roetto, Uwe Platzbecker, Lorenz C. Hofbauer   +6 more
doaj   +1 more source

New Candidate Delivery System for Alzheimer’s Disease: Deferoxamine Nanogels

, 2020
This study presents hydrogel nanoparticles made of chitosan and tripolyphosphate via ionotropic gelation technique to evaluate their potential for the association of deferoxamine.
Hajar Ashrafi, Amir Azadi, Soliman Mohammadi‐Samani, Mehrdad Hamidi, M Hamidi, H Ashrafi, A Azadi, R Narayanaswamy, V Torchilin, C Lin, A Metters, L Jahromi, F Panah, A Azadi, H Ashrafi, U Gaur, S Sahoo, T De, P Ghosh, A Maitra, P Ghosh, K Soppimath, T Aminabhavi, A Kulkarni, W Rudzinski, S Moghimi, A Hunter, J Murray, S Agnihotri, N Mallikarjuna, T Aminabhavi, J Wang, X Cheng, X Zhang, G Liu, Y Wang, W Zhou, Y Zhang, Q Gan, T Wang, M Cardia, A Carta, P Caboni, A Maccioni, S Erb, L Boi, M Meloni, F Lai, C Sinico, B Kisby, J Jarrell, M Agar, D Cohen, E Rosin, C Cahill, J Rogers, X Huang, X Wang, F Guan, J Fine, J Kosyakovsky, A Baillargeon, J Tokarev, J Cooner, A Svitak, K Faltesek, W Frey, L Hanson, J Porter, D Duscher, A Trotsyuk, Z Maan, S Kwon, M Rodrigues, K Engel, Z Stern-Buchbinder, C Bonham, J Barrera, A Whittam, P Holden, L Nair, H Akncolu, Glin, E Tan, K Johnell, J Bell, S Garcia-Ptacek, J Fastbom, P Nordstrm, M Eriksdotter, Y Yang, R Liscic, J Dominguez, C Then, K Liu, M Liao, K Chung, J Wang, S Shen, M Ali   +99 more
openalex   +2 more sources

Deferoxamine-Modified Hybrid Materials for Direct Chelation of Fe(III) Ions from Aqueous Solutions and Indication of the Competitiveness of In Vitro Complexing toward a Biological System

ACS Omega, 2021
Deferoxamine (DFO) is one of the most potent iron ion complexing agent belonging to a class of trihydroxamic acids. The extremely high stability constant of the DFO–Fe complex (log β = 30.6) prompts the use of deferoxamine as a targeted receptor for ...
Mateusz Pawlaczyk, G. Schroeder
semanticscholar   +1 more source

Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice

Marine Drugs, 2014
Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available.
Yajun Yang, Jing Ma, Jinghui Xiu, Lin Bai, Feifei Guan, Li Zhang, Jiangning Liu, Lianfeng Zhang   +7 more
doaj   +1 more source

How early can myocardial iron overload occur in Beta thalassemia major? [PDF]

, 2014
BACKGROUND: Myocardial siderosis is the most common cause of death in patients with beta thalassemia major(TM). This study aimed at investigating the occurrence, prevalence and severity of cardiac iron overload in a young Chinese population with beta TM.
A Aessopos, AM Maceira, AW Leung, B Modell, B Modell, B Modell, BA Davis, C Borgna-Pignatti, DH Fitchett, DJ Weatherall, DT Kremastinos, F Alpendurada, G Barosi, Gaohui Yang, GM Brittenham, GM Brittenham, HF Pan, Hongfei Pan, JC Wood, JC Wood, JC Wood, JL Fernandes, K Tziomalos, Liling Long, Lisa Anderson, LJ Anderson, LJ Anderson, M Angastiniotis, M Bejaoui, M Westwood, MA Aldouri, MA Tanner, MA Tanner, MA Tanner, MAEM Engle, NF Olivieri, P Kirk, Peng Peng, Q Meng, Rongrong Liu, Shaohong Tan, T He, Taigang He, V Positano, Weijia Yang, Xiaolei Xu, Xingjiang Long, Xinhua Zhang, Yong-rong Lai, Yongrong Lai   +49 more
core   +2 more sources

Effect of Deferoxamine on Outcome According to Baseline Hematoma Volume: A Post Hoc Analysis of the i-DEF Trial

Stroke, 2021
Background: Hematoma volume (HV) is a powerful determinant of outcome after intracerebral hemorrhage. We examined whether the effect of the iron chelator, deferoxamine, on functional outcome varied depending on HV in the i-DEF trial (Intracerebral ...
Chenchen Wei, Jeffrey Wang, L. Foster, S. Yeatts, C. Moy, J. Mocco, M. Selim, Y. Palesch, Jessica S. Griffin, Aaron Perlmutter, Casey Norton, Catherine R Dillon, Andre Thornhill, Steven Greenberg, Lewis B. Morgenstern, Daniel F. Hanley, Guohua Xi, Tom Bleck, Robert Balk, Wenle Zhao, Jaemyung Kim, Sandeep Kumar, Megan Farinella, Erica Siwila-Sackman, Caroline Feigert, Gottfried Schlaug, Jasmine Wang, Clinton Wright, Scott Janis, Peter Gilbert, Carlos S. Kase, Shannon Carson, Matthew L Flaherty, Craig M Kessler, Leslie A McClure, Donna Bannon, Joseph P. Broderick, Amy Dill   +37 more
semanticscholar   +1 more source