Apotransferrin Protects Cortical Neurons from Hemoglobin Toxicity [PDF]
, 2011 The protective effect of iron chelators in experimental models of intracerebral hemorrhage suggests that nonheme iron may contribute to injury to perihematomal cells.
Chen, Lifen +2 more
core +2 more sources
Asian Journal of Transfusion Science, 2017 Introduction: Beta-thalassemias are a cluster of inherited (autosomal recessive) hematological disorders prevalent in the Mediterranean area due to defects in synthesis of β chains of hemoglobin.
Hayder M Al-Kuraishy, Ali I Al-Gareeb
doaj +1 more source
Effect of Deferoxamine on Rat Fetal Bone Formation and on it is Certain Regulating Genes
Kufa Journal for Veterinary Medical Sciences, 2021 The aim of this study is to investigate the deferoxamine effect on rat fetal bone formation and on certain regulating genes expression that play a vital key role in bone formation.
Abeer Esmael Thanoon +1 more
doaj +1 more source
The increased susceptibility to hydrogen peroxide of the (post)-ischemic rat heart is associated with the magnitude of the low molecular weight iron pool [PDF]
, 1994 Recently we have shown that intracellular low molecular weight (LMW) iron increases during ischemia. It is hypothesized that this increase in LMW iron during ischemia underlies the reported hydrogen peroxide toxicity toward ischemic hearts.
Koster, J.F. (Johan) +2 more
core +2 more sources
Antibacterial and Angiogenic Poly(ionic liquid) Hydrogels
Gels, 2022 Wounds, particularly under low-hydration conditions, require more time to repair successfully. Therefore, there is an urgent need to develop wound dressings that can accelerate wound healing.
Chengju Sheng +5 more
doaj +1 more source
Use of single-chain antibody derivatives for targeted drug delivery [PDF]
, 2016 Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery.
Ahmadzadeh, V. +5 more
core +1 more source
Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine
Cancer Science, 2020 Cancer cells have high iron requirements due to their rapid growth and proliferation. Iron depletion using iron chelators has a potential in cancer treatment.
Kana Komoto +6 more
semanticscholar +1 more source
Long-term treatment with deferiprone enhances left ventricular ejection function when compared to deferoxamine in patients with thalassemia major [PDF]
, 2013 Transfusion and iron chelation treatment have significantly reduced morbidity and improved survival of patients with thalassemia major. However, cardiac disease continues to be the most common cause of death.
Barone, R +18 more
core +1 more source
Combating iron overload: a case for deferoxamine-based nanochelators.
Nanomedicine, 2020 While iron is a nutrient metal, iron overload can result in multiple organ failures. Iron chelators, such as deferoxamine, are commonly used to ameliorate iron overload conditions.
Gregory Jones +4 more
semanticscholar +1 more source
Deferoxamine: An Angiogenic and Antioxidant Molecule for Tissue Regeneration
Tissue engineering. Part B, Reviews, 2019 Deferoxamine (DFO) has been in use for half a century as a Food and Drug Administration-approved iron chelator, but recent studies indicate a variety of properties that could expand this drug's application into the fields of tissue and regenerative ...
Paige Holden, Lakshmi R Nair
semanticscholar +1 more source