Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration [PDF]
Frontiers in Synaptic Neuroscience, 2019 Protein palmitoylation is the post-translational, reversible addition of a 16-carbon fatty acid, palmitate, to proteins. Protein palmitoylation has recently garnered much attention, as it robustly modifies the localization and function of canonical ...
Kevin P. Koster +3 more
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Melatonin protects aged oocytes from depalmitoylation-mediated quality reduction by promoting PPT1 degradation and antioxidation [PDF]
Redox BiologyOocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications.
Rujun Ma +21 more
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Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice [PDF]
Nature CommunicationsPrecise regulation of type I interferon signaling is crucial for effective immune defense against infectious diseases. However, the molecular mechanisms governing this pathway are not fully understood.
Zhongxin Han +10 more
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Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads [PDF]
Nature Communications, 2019 Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit ...
Shuyang Chen +15 more
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Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes [PDF]
Nature Communications, 2018 S-palmitoylation regulation has been studied mostly in the cytosol and its role in mitochondria is unclear. Here the authors develop fluorescent mitochondria-targeted probes and find that depalmitoylation occurs in mitochondria and it’s influenced by ...
Rahul S. Kathayat +9 more
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Influence of palmitoylation in axonal transport mechanisms in neurodegenerative diseases [PDF]
Frontiers in Cellular NeuroscienceProgressive functional loss and death of neurons are characteristics of neurodegenerative diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD).
Praveen B. S., Priti Talwar
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Restoration of Osimertinib sensitivity in lung cancer through BRD4 inhibitor-mediated depalmitoylation of mutant EGFR via APT1 [PDF]
npj Precision OncologyNon-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations initially responds to the third-generation EGFR-tyrosine kinase inhibitor (TKI) Osimertinib.
Wolong Zhou +6 more
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PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism
iScience, 2023 Summary: Ovarian granulosa cells (GCs) in the follicle are the important mediator of steroidogenesis and foster oocyte maturation. Evidences suggested that the function of GCs could be regulated by S-palmitoylation.
Tongmin Xue +13 more
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Depalmitoylase ABHD16A negatively regulates the anti-hepatitis B virus activity of IFITM1 [PDF]
Microbiology SpectrumInterferon-inducible transmembrane (IFITM) proteins have been widely reported as antiviral factors against various viral pathogens. However, the mechanisms of IFITM regulation on hepatitis B virus (HBV), which induces chronic infection resulting in ...
Xin Wen +8 more
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S-palmitoylation modulates ATG2-dependent non-vesicular lipid transport during starvation-induced autophagy [PDF]
The EMBO JournalLipid transfer proteins mediate the non-vesicular transport of lipids at membrane contact sites to regulate the lipid composition of organelle membranes. Despite significant recent advances in our understanding of the structural basis for lipid transfer,
Wenhui Zheng +9 more
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