Results 91 to 100 of about 2,734 (187)

S-acylation of the insulin-responsive aminopeptidase (IRAP) : quantitative analysis and identification of modified cysteines [PDF]

, 2015
The insulin-responsive aminopeptidase (IRAP) was recently identified as an S-acylated protein in adipocytes and other tissues. However, there is currently no information on the extent of S-acylation of this protein, the residues that are modified, or the
Chamberlain, Luke H., Werno, Martin W.
core   +1 more source

Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis

Frontiers in Synaptic Neuroscience
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation.
Kevin P. Koster, Zach Fyke, Thu T. A. Nguyen, Amanda Niqula, Lorena Y. Noriega-González, Kevin M. Woolfrey, Mark L. Dell’Acqua, Stephanie M. Cologna, Akira Yoshii, Akira Yoshii, Akira Yoshii   +10 more
doaj   +1 more source

Inhibition of NRAS Signaling in Melanoma through Direct Depalmitoylation Using Amphiphilic Nucleophiles

ACS Chemical Biology, 2020
Activating mutations in the small GTPase NRAS are responsible for driving tumor growth in several cancers. Unfortunately, the development of NRAS inhibitors has proven difficult due to the lack of hydrophobic binding pockets on the protein's surface. To overcome this limitation, we chose to target the post-translational S-palmitoyl modification of NRAS,
Hetika D. Vora, Mai Johnson, Roberto J. Brea, Andrew K. Rudd, Neal K. Devaraj   +4 more
openaire   +3 more sources

The Ins and Outs of miRNA-Mediated Gene Silencing during Neuronal Synaptic Plasticity [PDF]

, 2016
Neuronal connections through specialized junctions, known as synapses, create circuits that underlie brain function. Synaptic plasticity, i.e., structural and functional changes to synapses, occurs in response to neuronal activity and is a critical ...
Hanley, Jonathan, Rajgor, Dipen
core   +3 more sources

Transient Suppression of Dopamine Transporter Palmitoylation by Methamphetamine: Implications for Transport Regulation

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
This study examines the effects of METH on dopamine transporter (DAT) palmitoylation, a modification that enhances transport velocity and opposes PKC‐induced down‐regulation. In rats injected with METH, DAT palmitoylation was suppressed within minutes followed by a gradual return to control levels. METH‐induced transport down‐regulation occurred within
Moriah J. Hovde, Danielle E. Bolland, Corey D. Kleinsasser, Madhur Shetty, Aaron C. Blackwell, Mikhail Y. Golovko, Svetlana A. Golovko, Christopher R. Brown, James D. Foster, Roxanne A. Vaughan   +9 more
wiley   +1 more source

The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function

Frontiers in Cellular Neuroscience, 2019
Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures.
Tamar Sapir, Michal Segal, Gayane Grigoryan, Karin M. Hansson, Peter James, Peter James, Menahem Segal, Orly Reiner   +7 more
doaj   +1 more source

Palmitoyl Acyltransferase DHHC21 Mediates Endothelial Dysfunction in Systemic Inflammatory Response Syndrome [PDF]

, 2016
Endothelial dysfunction is a hallmark of systemic inflammatory response underlying multiple organ failure. Here we report a novel function of DHHC-containing palmitoyl acyltransferases (PATs) in mediating endothelial inflammation.
Beard, Richard S., Jr.
core   +1 more source

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Palmitoylation is required for TNF-R1 signaling

Cell Communication and Signaling, 2019
Background Binding of tumor necrosis factor (TNF) to TNF-receptor 1 (TNF-R1) can induce either cell survival or cell death. The selection between these diametrically opposed effects depends on the subcellular location of TNF-R1: plasma membrane retention
Philipp Zingler, Vinzenz Särchen, Timo Glatter, Lotta Caning, Carina Saggau, Rahul S. Kathayat, Bryan C. Dickinson, Dieter Adam, Wulf Schneider-Brachert, Stefan Schütze, Jürgen Fritsch   +10 more
doaj   +1 more source

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway [PDF]

The Journal of Cell Biology, 2005
Palmitoylation is postulated to regulate Ras signaling by modulating its intracellular trafficking and membrane microenvironment. The mechanisms by which palmitoylation contributes to these events are poorly understood. Here, we show that dynamic turnover of palmitate regulates the intracellular trafficking of HRas and NRas to and from the Golgi ...
Goodwin, J. Shawn, Drake, Kimberly R., Rogers, Carl, Wright, Latasha, Lippincott-Schwartz, Jennifer, Philips, Mark R., Kenworthy, Anne K.   +6 more
openaire   +2 more sources