Results 101 to 110 of about 2,734 (187)

Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. [PDF]

, 1994
The smaller isoform of the GABA synthesizing enzyme glutamic acid decarboxylase, GAD65, is synthesized as a soluble protein that undergoes post-translational modification(s) in the NH2-terminal region to become anchored to the membrane of small synaptic ...
Baekkeskov, Steinunn, Shi, Y, Veit, B
core  

miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a [PDF]

, 2016
A single microRNA (miRNA) can regulate expression of multiple proteins, and expression of an individual protein may be controlled by numerous miRNAs.
Bian, G, Fang, C, Ju, G, Liu, F, Liu, L, Song, B, Wang, J, Wang, Y, Xue, Q, Yang, A, Yu, C, Zhang, K   +11 more
core   +1 more source

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, Volume 15, Issue 10, Page 1678-1695, October 2025.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Quantitative analysis of the human T cell palmitome [PDF]

, 2015
Palmitoylation is a reversible post-translational modification used to inducibly compartmentalize proteins in cellular membranes, affecting the function of receptors and intracellular signaling proteins.
Brügger, Britta, Freund, Christian, Kliche, Stefanie, Krause, Eberhard, Kuropka, Benno, Morrison, Eliot   +5 more
core   +1 more source

ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty Acids

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin, Yulong Hong, Yongqi Zhao, Wensheng Shi, Ruilin Liu, Xinyu You, Chong Yang, Yu Zhang   +7 more
wiley   +1 more source

Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation [PDF]

, 2013
Biochemical properties of Ras oncoproteins and their transforming ability strongly support a dominant mechanism of action in tumorigenesis. However, genetic studies unexpectedly suggested that wild-type (WT) Ras exerts tumor suppressor activity ...
Chen, Shann-Ching, Davis, Elizabeth, Downing, James, Firestone, Ari J., Haigis, Kevin M., Jacks, Tyler E, Le Beau, Michelle M., Li, Qing, McNerney, Megan E., Nakitandwe, Joy, Shannon, Kevin, Xu, Jin   +11 more
core   +2 more sources

Palmitoyl‐Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing‐Related Human Neuronal Lipofuscin

Neuropathology and Applied Neurobiology, Volume 51, Issue 5, October 2025.
ABSTRACT Proteomics of laser‐dissected lipofuscin from aged, healthy brains reveals Palmitoyl‐Protein Thioesterase 1 (PPT1) and other CLN proteins as constituents. PPT1 is increasingly sequestered to lipofuscin during ageing. Protein sequestering into lipofuscin may contribute to physiological neuronal ageing.
Max Anstötz, Sarah Tschirner, Caroline May, Steffen Kösters, Christine Martin, Svenja Caspers, Eleonora Aronica, Hans Jürgen Bidmon, Katrin Marcus, Carsten Korth   +9 more
wiley   +1 more source

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis [PDF]

, 2011
hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors).
Alyn H. Morice, Andrew Botham, Bijlmakers, Blanpain, Bockaert, Bockaert, Bohm, Carvou, Compton, Compton, Compton, DeFea, Dery, Doi, Eason, Escriba, Hansen, Hawtin, Hayashi, Heuser, Jiang, Kawate, Klinger, Krasel, Krupnick, Kumar, Lafleur, Laura R. Sadofsky, Ma, McCoy, Melkonian, Moffett, Moffett, Molino, Moore, Munshi, Oh, Okamoto, Okamoto, Palmer, Percherancier, Petaja-Repo, Piersen, Ponimaskin, Qanbar, Rimoldi, Sadeghi, Seatter, Shenoy, Stalheim, Steven J. Compton, Wei, Xiaodan Guo, Yu Pei Xiao, Zoudilova   +54 more
core   +5 more sources

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

Advanced Science, Volume 12, Issue 34, September 11, 2025.
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
wiley   +1 more source

Enhancing Gpx1 palmitoylation to inhibit angiogenesis by targeting PPT1

Redox Biology
The significance of protein S-palmitoylation in angiogenesis has been largely overlooked, leaving various aspects unexplored. Recent identification of Gpx1 as a palmitoylated protein has generated interest in exploring its potential involvement in novel ...
Yidan Ma, Xinxin Yuan, Aodong Wei, Xiaopeng Li, Azim Patar, Shaobo Su, Songtao Wang, Gaoen Ma, Jiangli Zhu, Eryan Kong   +9 more
doaj   +1 more source