Results 111 to 120 of about 2,734 (187)
Enzymatic Depalmitoylation of Viral Glycoproteins with Acyl-Protein Thioesterase 1 in Vitro
Virology, 2001 Many glycoproteins of enveloped viruses as well as cellular proteins are covalently modified with fatty acids. Palmitoylation is often reversible, but the enzymology of this hydrophobic protein modification is not understood. Recently a cytosolic enzyme designated acyl-protein thioesterase 1 (APT1) was purified, which depalmitoylates several cellular ...
Veit, Michael, Schmidt, Michael F.G.
openaire +2 more sources
An outlook on protein S-acylation in plants:what are the next steps? [PDF]
, 2017 S-acylation, also known as palmitoylation, is the reversible post-translational addition of fatty acids to proteins. Historically thought primarily to be a means for anchoring otherwise soluble proteins to membranes, evidence now suggests that reversible
Hemsley, Piers A.
core +2 more sources
ZDHHC5 Mediates Immune Dysregulation Driving Generalized Anxiety Disorder Risk
Brain and Behavior, Volume 15, Issue 9, September 2025.Mendelian randomization identifies palmitoylation genes driving generalized anxiety disorder (GAD) risk, notably ZDHHC5 and ZDHHC13. ZDHHC5 promotes GAD pathogenesis by modulating SSC‐A on CD4+ T cells, revealing novel immune‐mediated mechanisms and therapeutic targets for GAD.
Fuqiang Sun +8 more
wiley +1 more source
Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling [PDF]
, 2012 Background A cholesterol-palmitoyl interaction has been reported to occur in the dimeric interface of the β2-adrenergic receptor crystal structure. We sought to investigate whether a similar phenomenon could be observed with μ-opioid receptor (OPRM1 ...
Hui Zheng +8 more
core +1 more source
Journal of Extracellular Vesicles, Volume 14, Issue 8, August 2025.Extracellular vesicles from Limosilactobacillus johnsonii reach the mammary gland through the gut‐mammary axis, where their palmitic acid (C16:0) induce the dynamic changes in CD36 palmitoylation in mammary epithelial cells, thereby facilitating fatty acid uptake as substrates and enhance milk fat synthesis in HC11 cells via PPARγ signalling.
Qihui Li +8 more
wiley +1 more source
eLife, 2018 Wnt5a has been implicated in melanoma progression and metastasis, although the exact downstream signaling events that contribute to melanoma metastasis are poorly understood.
Rochelle Shirin Sadeghi +6 more
doaj +1 more source
An Amphipathic α-Helix Directs Palmitoylation of the Large Intracellular Loop of the Sodium/Calcium Exchanger [PDF]
, 2017 The electrogenic sodium/calcium exchanger (NCX) mediates bidirectional calcium transport controlled by the transmembrane sodium gradient. NCX inactivation occurs in the absence of phosphatidylinositol 4,5-bisphosphate and is facilitated by palmitoylation
Blanc +31 more
core +3 more sources
VIEW, Volume 6, Issue 3, June 2025.Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) poses a significant public health risk, yet effective treatments are limited due to the lack of suitable models. This study developed a more realistic model of SI‐ALI using organ‐on‐a‐chip and organoid technologies, identified key molecules such as catechol‐O‐methyltransferase and ...
Junmin Li +12 more
wiley +1 more source
NCLs and ER: A stressful relationship. [PDF]
, 2017 The Neuronal Ceroid Lipofuscinoses (NCLs, Batten disease) are a group of inherited neurodegenerative disorders with variable age of onset, characterized by the lysosomal accumulation of autofluorescent ceroid lipopigments.
Marotta, D, Mole, SE, Tinelli, E
core +1 more source
Depalmitoylation of CAAX Motif Proteins [PDF]
Journal of Biological Chemistry, 1995 Jui-Yun Lu, Sandra L. Hofmann
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