Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1 [PDF]
Cell Calcium, 2021 Catalyzed by zDHHC-PAT enzymes and reversed by thioesterases, protein palmitoylation is the only post-translational modification recognized to regulate the sodium/calcium exchanger NCX1. NCX1 palmitoylation occurs at a single site at position 739 in its large regulatory intracellular loop.
Caglar Gök +8 more
openaire +8 more sources
Palmitoylation: an emerging therapeutic target bridging physiology and disease [PDF]
Cellular & Molecular Biology LettersPalmitoylation is a reversible post-translational lipid modification of proteins, catalyzed by the Zinc finger DHHC domain-containing (ZDHHC) family of palmitoyltransferases.
Weini Li +7 more
doaj +2 more sources
Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6
Cell ReportsSummary: Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity.
Jacqueline Howie +11 more
doaj +4 more sources
Inhibition of BRD4 sensitizes NSCLC cells to osimertinib by suppressing APT1 and promoting MST1 palmitoylation [PDF]
Cell Death DiscoveryOsimertinib is widely used to treat non-small-cell lung cancer (NSCLC) carrying epidermal growth factor receptor (EGFR) mutations. However, osimertinib resistance inevitably develops in almost all patients.
Shaoqiang Wang +5 more
doaj +2 more sources
Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma [PDF]
ResearchBackground: Osteosarcoma (OS) is a primary malignant bone tumor predominantly affecting adolescents. Chemotherapeutic agents, such as cisplatin, are commonly used in OS treatment; however, drug resistance markedly undermines treatment efficacy and ...
Tianlong Huang +9 more
doaj +2 more sources
Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses [PDF]
BiomoleculesProtein S-palmitoylation is a pivotal yet poorly integrated research field in dermatology. This reversible post-translational lipid modification primarily occurs on cysteine residues and is principally catalyzed by zinc finger and Asp-His-His-Cys DHHC ...
Yanhai Feng +9 more
doaj +2 more sources
ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
Cell ReportsSummary: LMNA gene mutation can cause muscular dystrophy, and post-translational modification plays a critical role in regulating its function. Here, we identify that lamin A is palmitoylated at cysteine 522, 588, and 591 residues, which are reversely ...
Yuan Shen +10 more
doaj +3 more sources
Engineered depalmitoylases enable selective manipulation of protein localization and function [PDF]
Nature CommunicationsS-Palmitoylation is a reversible post-translational modification that tunes the localization, stability, and function of an impressive array of proteins including ion channels, G-proteins, and synaptic proteins.
Srinidhi Jayaraman +4 more
doaj +2 more sources
The Unconventional Role of ABHD17A in Increasing the S-Palmitoylation and Antiviral Activity of IFITM1 by Downregulating ABHD16A [PDF]
BiomoleculesThe broad-spectrum antiviral functions of interferon-inducible transmembrane 1 (IFITM1) rely on S-palmitoylation post-translational modification.
Xuemeng Shi +11 more
doaj +2 more sources
Swine RNF5 positively regulates the antiviral activity of IFITM1 by mediating the degradation of ABHD16A [PDF]
Journal of VirologyInterferon-inducible transmembrane (IFITM) proteins are broad-spectrum antiviral factors that confer cellular resistance to virus invasion. α/β-Hydrolase domain-containing 16A (ABHD16A) has recently been identified as a novel depalmitoylase that can ...
Xuemeng Shi +10 more
doaj +2 more sources