Results 21 to 30 of about 2,734 (187)

Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases [PDF]

Frontiers in Immunology
Protein palmitoylation is a reversible lipid modification in which palmitoyl esters are covalently attached to cysteine residues of proteins. It controls various cellular physiological processes and alters protein stability, conformation, localization ...
Rong Chen, Rong Chen, Xiaohua Tang, Ying Wang, Bo Wang, Fei Mao, Fei Mao   +6 more
doaj   +2 more sources

Analysis and validation of novel biomarkers related to palmitoylation in adenomyosis [PDF]

Frontiers in Genetics
BackgroundAdenomyosis, a common gynecological disorder in women of reproductive age, is characterized by endometrial invasion into the myometrium, leading to uterine enlargement and smooth muscle hypertrophy.
Hongyu Zhang, Yufeng Li, Huijuan Cao, Yiling Zhao, Hongwen Zhu, Tiansheng Qin   +5 more
doaj   +2 more sources

Nanobody-thioesterase chimeras to specifically target protein palmitoylation [PDF]

Nature Communications
The complexity of the cellular proteome is massively expanded by a repertoire of chemically distinct reversible post-translational modifications (PTMs) that control protein localisation, interactions, and function.
Chien-Wen Kuo, Caglar Gök, Hannah Fulton, Eleanor Dickson-Murray, Samuel Adu, Emily K. Gallen, Sheon Mary, Alan D. Robertson, Fiona Jordan, Emma Dunning, William Mullen, Godfrey L. Smith, William Fuller   +12 more
doaj   +2 more sources

APT1-derived depalmitoylation of CD36 alleviates diabetes-induced lipotoxicity in podocytes. [PDF]

Int J Biol Sci
Cluster of Differentiation 36 (CD36), also known as scavenger receptor B2, plays a critical role in controlling podocyte lipid metabolism, mediating the onset and progression of diabetic kidney disease (DKD). However, the post-translational regulation of CD36 and its exact role in lipid transport within podocytes remain unclear.
Wang J, Hu J, Hu H, Guan Q, Zhu Z, Yang Q, Ding G.   +6 more
europepmc   +2 more sources

Trypanosoma brucei Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity

Pathogens, 2022
Dynamic post-translational modifications allow the rapid, specific, and tunable regulation of protein functions in eukaryotic cells. S-acylation is the only reversible lipid modification of proteins, in which a fatty acid, usually palmitate, is ...
Robert W. B. Brown, Aabha I. Sharma, Miguel Rey Villanueva, Xiaomo Li, Ouma Onguka, Leeor Zilbermintz, Helen Nguyen, Ben A. Falk, Cheryl L. Olson, Joann M. Taylor, Conrad L. Epting, Rahul S. Kathayat, Neri Amara, Bryan C. Dickinson, Matthew Bogyo, David M. Engman   +15 more
doaj   +1 more source

Protein Lipidation by Palmitoylation and Myristoylation in Cancer

Frontiers in Cell and Developmental Biology, 2021
Posttranslational modification of proteins with lipid moieties is known as protein lipidation. The attachment of a lipid molecule to proteins endows distinct properties, which affect their hydrophobicity, structural stability, localization, trafficking ...
Chee Wai Fhu, Azhar Ali
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.

PLoS Biology, 2022
Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease.
Erica L Gorenberg, Sofia Massaro Tieze, Betül Yücel, Helen R Zhao, Vicky Chou, Gregory S Wirak, Susumu Tomita, TuKiet T Lam, Sreeganga S Chandra   +8 more
doaj   +1 more source

Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies

Frontiers in Physiology, 2022
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date.
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller   +11 more
doaj   +1 more source

The role of lysosomal depalmitoylation in Alzheimer's Disease in vitro and in vivo models [PDF]

Alzheimers Dement
Abstract Background Amyloidogenic proteins are palmitoylated, and changes in palmitoylation may affect Aβ plaques in AD (Alzheimer's Disease). Palmitoylation enriches amyloidogenic proteins in lipid rafts, while deficiency retains them in the endoplasmic reticulum, inhibiting Aβ accumulation.
Romero S, Lai M, Rosene M, Herrera N, Lopez A, Gonzalez G, Ahmad A, Patton J, Muratore C, Benitez B.   +9 more
europepmc   +2 more sources