Results 31 to 40 of about 2,734 (187)
CD36 and Its Role in Obesity. [PDF]
Obes RevABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Garcia N +5 more
europepmc +2 more sources
Identification of PSD-95 Depalmitoylating Enzymes [PDF]
The Journal of Neuroscience, 2016 Postsynaptic density (PSD)-95, the most abundant postsynaptic scaffolding protein, plays a pivotal role in synapse development and function. Continuous palmitoylation cycles on PSD-95 are essential for its synaptic clustering and regulation of AMPA receptor function.
Norihiko, Yokoi +5 more
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APT1-Mediated Depalmitoylation Regulates Hippocampal Synaptic Plasticity
The Journal of Neuroscience, 2022 Palmitoylation may be relevant to the processes of learning and memory, and even disorders, such as post-traumatic stress disorder and aging-related cognitive decline. However, underlying mechanisms of palmitoylation in these processes remain unclear. Herein, we used acyl-biotin exchange, coimmunoprecipitation and biotinylation assays, and behavioral ...
Zu-Cheng Shen +12 more
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Palmitoylation and depalmitoylation dynamics at a glance [PDF]
Journal of Cell Science, 2010 Protein palmitoylation, the thioester linkage of fatty acyl moieties (typically, saturated 16C palmitate) to cysteine, is a lipid modification that serves both to tether proteins to membranes and to direct their localization to membrane microdomains.
Elizabeth, Conibear, Nicholas G, Davis
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Depalmitoylation rewires FLT3-ITD signaling and exacerbates leukemia progression
Blood, 2021 Abstract Internal tandem duplication within FLT3 (FLT3-ITD) is one of the most frequent mutations in acute myeloid leukemia (AML) and correlates with a poor prognosis. Whereas the FLT3 receptor tyrosine kinase is activated at the plasma membrane to transduce PI3K/AKT and RAS/MAPK signaling, FLT3-ITD resides in the endoplasmic ...
Kaosheng Lv +5 more
openaire +3 more sources
Role of the transmembrane domain in severe acute respiratory syndrome (SARS) coronavirus 2 spike for palmitoylation and membrane fusion. [PDF]
Protein SciAbstract Palmitoylation is a reversible post‐translational modification that enhances protein hydrophobicity and regulates cellular functions such as trafficking and signaling. In humans, this modification is catalyzed by 23 DHHC enzymes, but the mechanisms by which they recognize their substrates remain unclear.
Abdulrahman DA, Veit M.
europepmc +2 more sources
Palmitoylation and depalmitoylation defects [PDF]
Journal of Inherited Metabolic Disease, 2014 AbstractPalmitoylation describes the enzymatic attachment of a 16‐carbon atom fatty acid to a target protein. Such lipidation events occur in all eukaryotes and can be of reversible (S‐palmitoylation) or irreversible (N‐palmitoylation) nature. In particular S‐palmitoylation is dynamically regulated by two opposing types of enzymes which add (palmitoyl ...
openaire +4 more sources
ABHD16A Negatively Regulates the Palmitoylation and Antiviral Function of IFITM Proteins
mBio, 2022 Interferon-inducible transmembrane (IFITM) proteins are small homologous proteins that are encoded by the interferon-stimulated genes (ISGs), which can be strongly induced by interferon (IFN) and provide resistance to invasion by a variety of viral ...
Xuemeng Shi +8 more
doaj +1 more source
A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis [PDF]
, 2017 Autosomal-dominant adult-onset neuronal cero id lipofuscinosis (ANCL) is caused by mutation of the DNAJC5 gene encoding cysteine string protein alpha (CSP α ). The disease- causing mutations, which result in substituti on of leucine-115 with an arginine (
Chamberlain, Luke H. +4 more
core +1 more source
eLife, 2015 Dynamic changes in protein S-palmitoylation are critical for regulating protein localization and signaling. Only two enzymes - the acyl-protein thioesterases APT1 and APT2 – are known to catalyze palmitate removal from cytosolic cysteine residues.
David Tse Shen Lin, Elizabeth Conibear
doaj +1 more source