KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion. [PDF]
Adv Sci (Weinh)Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Li M +12 more
europepmc +2 more sources
FKBP12 Binds to Acylated H-Ras and Promotes Depalmitoylation [PDF]
Molecular Cell, 2011 A cycle of palmitoylation/depalmitoylation of H-Ras mediates bidirectional trafficking between the Golgi apparatus and the plasma membrane, but nothing is known about how this cycle is regulated. We show that the prolyl isomerase (PI) FKBP12 binds to H-Ras in a palmitoylation-dependent fashion and promotes depalmitoylation.
Ahearn, Ian M. +8 more
openaire +2 more sources
Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation [PDF]
, 2016 Cardiac voltage-gated sodium channels (Nav1.5) play an essential role in regulating cardiac electric activity by initiating and propagating action potentials in the heart.
Cummins, Theodore R. +4 more
core +1 more source
A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling [PDF]
Nature Chemical Biology, 2016 Hundreds of human proteins are modified by reversible palmitoylation of cysteine residues (S-palmitoylation), but the regulation of depalmitoylation is poorly understood. Here, we develop 'depalmitoylation probes' (DPPs), small-molecule fluorophores, to monitor the endogenous activity levels of 'erasers' of S-palmitoylation, acylprotein thioesterases ...
Kathayat, Rahul S. +2 more
openaire +2 more sources
Palmitoylated ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis [PDF]
, 2010 Ras proteins regulate cell growth, death, and differentiation, and it is well established that this functional versatility is accomplished through their different subcellular localizations.
Ang +38 more
core +1 more source
Depalmitoylation of Ykt6 Prevents its Entry into the Multivesicular Body Pathway [PDF]
Traffic, 2008 The dually lipidated SNARE Ykt6 is found on intracellular membranes and in the cytosol. In this study, we show that Ykt6 localizes to the Golgi as well as endosomal and vacuolar membranes in vivo. The ability of Ykt6 to cycle between the cytosol and the membranes depends on the intramolecular interaction of the N‐terminal longin and C‐terminal SNARE ...
Christoph T A, Meiringer +3 more
openaire +2 more sources
ATP-independent Control of Vac8 Palmitoylation by a SNARE Subcomplex on Yeast Vacuoles [PDF]
, 2005 Yeast vacuole fusion requires palmitoylated Vac8. We previously showed that Vac8 acylation occurs early in the fusion reaction, is blocked by antibodies against Sec18 (yeast N-ethylmaleimide-sensitive fusion protein (NSF)), and is mediated by the R-SNARE
Cristodero, Marina +5 more
core +1 more source
Cellular signaling and NO production [PDF]
, 2010 The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor is nitric oxide (NO), which is synthesized by the endothelial ...
Michel, T, Vanhoutte, PM
core +1 more source
Understanding the rules governing NCX1 palmitoylation [PDF]
, 2017 No abstract ...
Blanc M +4 more
core +3 more sources
Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity
Frontiers in Molecular Neuroscience, 2019 Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics.
Lucas Matt +3 more
doaj +1 more source