Identification of novel post-transcriptional features in olfactory receptor family mRNAs. [PDF]
, 2015 Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance in olfaction, how most Olfr mRNAs are regulated remains unexplored.
Espinoza, Josh L +3 more
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ABHD1/12‐mediated TEADs depalmitoylation regulates Hippo pathway transcriptional output
The FASEB Journal, 2021 TEAD domain (TEAD) transcription factors bind with the transcription co‐activator YAP/TAZ and regulate the transcriptional output of Hippo pathway, thus controlling organ size and tumorigenesis. Our lab previously identified that TEADs possessed intrinsic palmitoylating enzyme‐like activities and underwent autopalmitoylation, which
Zhipeng Tao +6 more
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Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis [PDF]
, 2017 Mutations in the co- chaperone protein, CSPα, cause an autosomal dominant, adult-neuronal ceroid lipofuscinosis (AD-ANCL). The current understanding of CSPα function exclusively at the synapse fails to explain the autophagy-lysosome pathway (ALP ...
Benitez, Bruno A, Sands, Mark S
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eLife, 2019 Protein palmitoylation and depalmitoylation alter protein function. This post-translational modification is critical for synaptic transmission and plasticity.
Kevin P Koster +5 more
doaj +1 more source
In vitro depalmitoylation assay v1
, 2023 This protocol describes the in vitro depalmitoylation assay of DNAJC5
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Persistent membrane association of activated and depalmitoylated G protein α subunits [PDF]
Proceedings of the National Academy of Sciences, 1999 Heterotrimeric signal-transducing G proteins are organized at the inner surface of the plasma membrane, where they are positioned to interact with membrane-spanning receptors and appropriate effectors. G proteins are activated when they bind GTP and inactivated when they hydrolyze the nucleotide to GDP.
C, Huang +3 more
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The physiology of protein S-acylation [PDF]
, 2015 Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is emerging as a ubiquitous mechanism to control the properties and function of a diverse array of proteins and consequently physiological processes.
Chamberlain, Luke H. +1 more
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Individual Palmitoyl Residues Serve Distinct Roles in H-ras Trafficking, Microlocalization, and Signaling [PDF]
, 2005 H-ras is anchored to the plasma membrane by two palmitoylated cysteine residues, Cys181 and Cys184, operating in concert with a C-terminal S-farnesyl cysteine carboxymethylester. Here we demonstrate that the two palmitates serve distinct biological roles.
Roy, Sandrine +9 more
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MicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiology [PDF]
, 2018 Indexación: Scopus.1Laboratory of Neuroplasticity and Neurogenetics, Faculty of Chemical and Pharmaceutical Sciences, Department of Biochemistry and Molecular Biology, Universidad de Chile, Santiago, Chile, 2National Institute of Environmental Health ...
Aguayo, F.I. +12 more
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The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK [PDF]
, 2018 Upon engagement of the T cell receptor with an antigen-presenting cell, LCK initiates TCR signaling by phosphorylating its activation motifs. However, the mechanism of LCK activation specifically at the immune synapse is a major question.
Castro Sanchez, Patricia +6 more
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