Results 61 to 70 of about 2,734 (187)
Regenerative Therapy, 2023 Objective: Senile osteoporosis (SOP) is an aging-related disease. The depalmitoylating enzyme Acyl-protein thiesterase1 (APT1) is involved in disease regulation. This study explored the mechanism of APT1 in SOP.
Changjiao Ji +6 more
doaj +1 more source
Greasing the wheels or a spanner in the works?:Regulation of the cardiac sodium pump by palmitoylation [PDF]
, 2018 The ubiquitous sodium/potassium ATPase (Na pump) is the most abundant primary active transporter at the cell surface of multiple cell types, including ventricular myocytes in the heart.
Fiona Plain +10 more
core +3 more sources
Specific oligomerization of the 5-HT1A receptor in the plasma membrane [PDF]
, 2009 In the present study we analyze the oligomerization of the 5-HT1A receptor within living cells at the sub-cellular level. Using a 2-excitation Foerster Resonance Energy Transfer (FRET) method combined with spectral microscopy we are able to estimate the ...
Andrew Woehler +34 more
core +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 Protein palmitoylation—a lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl group—is a significant post-translational biological process. This process regulates the trafficking,
Xiaoling Li +5 more
doaj +1 more source
Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior [PDF]
Journal of Biological Chemistry, 2015 Wnt5a signaling regulates polarized cell behavior, but the downstream signaling events that promote cell polarity are not well understood. Our results show that Wnt5a promotes depalmitoylation of the melanoma cell adhesion molecule (MCAM) at cysteine 590.
Wei, Wang +4 more
openaire +2 more sources
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors [PDF]
, 2019 The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl ...
Bazovkina, Daria +9 more
core +1 more source
Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
Nature Communications, 2017 Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced ...
Selena S. Schattauer +8 more
doaj +1 more source
Palmitoylation of Plasmodium alveolins promotes cytoskeletal function. [PDF]
, 2017 S-palmitoylation is a post-translational lipid modification that is widespread among Plasmodium proteins and essential for parasite development. Little is known about the contribution of palmitoylation to the function of individual parasite molecules and
Al-Khattaf, Fatimah S +2 more
core +1 more source
Advanced Science, EarlyView.This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen +7 more
wiley +1 more source
Protein palmitoylation in cancer: molecular functions and therapeutic potential
Molecular Oncology, 2023 Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family.
Binhui Zhou +3 more
doaj +1 more source