Results 71 to 80 of about 2,734 (187)

Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

Molecular Cell, 2023
Cyclic GMP-AMP synthase (cGAS) binds pathogenic and other cytoplasmic double-stranded DNA (dsDNA) to catalyze the synthesis of cyclic GMP-AMP (cGAMP), which serves as the secondary messenger to activate the STING pathway and innate immune responses.
Yizeng, Fan, Yang, Gao, Li, Nie, Tao, Hou, Weichao, Dan, Zixi, Wang, Tianjie, Liu, Yi, Wei, Yuzhao, Wang, Bo, Liu, Taotao, Que, Yuzeshi, Lei, Jin, Zeng, Jian, Ma, Wenyi, Wei, Lei, Li   +15 more
openaire   +2 more sources

Palmitoylation and Membrane Association of the Stress Axis Regulated Insert (STREX) Controls BK Channel Regulation by Protein Kinase C [PDF]

, 2012
Large-conductance, calcium- and voltage-gated potassium (BK) channels play an important role in cellular excitability by controlling membrane potential and calcium influx.
Barman, Bell, Benkusky, Butler, Chen, El Husseini, Ferrer, Fukao, Fukata, Hall, Hamill, Holdiman, Jennings, Kundu, Lagrutta, Lai, Lin, Lovell, Mahmoud, Mahmoud, Meredith, Orio, Pickering, Quirk, Ruth, Rüttiger, Saito, Sausbier, Sausbier, Schubert, Schubert, Shipston, Shipston, Shipston, Tian, Tian, Tian, Tseng-Crank, Werner, White, Xie, Zhou, Zhou, Zhou, Zhu   +44 more
core   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

S-palmitoylation and depalmitoylation at the interface of animal virus-host interactions

Frontiers in Cellular and Infection Microbiology
Reversible protein S-palmitoylation, mediated by protein acyl transferases (PATs) and depalmitoylases, is essential for regulating numerous biological processes, including subcellular localization, protein stability, enzymatic activity, and protein ...
Rui-Qin Xu, Rui-Qin Xu, Xi-Meng Chen, Chen-Rong Wang, Shi-Jie Ma, Shi-Jie Ma, Shi-Jie Ma, Ping-Li Wang, Ping-Li Wang, Ping-Li Wang, Hong-Ying Chen, Hong-Ying Chen, Hong-Ying Chen   +12 more
doaj   +1 more source

Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation

Cell Reports, 2023
Summary: Substrate degradation by the ubiquitin proteasome system (UPS) in specific membrane compartments remains elusive. Here, we show that the interplay of two lipid modifications and PDE6δ regulates compartmental substrate targeting via the SCFFBXL2.
David Liang, Liping Jiang, Sameer Ahmed Bhat, Sonia Missiroli, Mariasole Perrone, Angela Lauriola, Ritika Adhikari, Anish Gudur, Zahra Vasi, Ian Ahearn, Daniele Guardavaccaro, Carlotta Giorgi, Mark Philips, Shafi Kuchay   +13 more
doaj   +1 more source

Regulator of Ras Depalmitoylation and Retrograde Trafficking: A New Hat for FKBP [PDF]

Molecular Cell, 2011
In this issue of Molecular Cell, Ahearn et al. (2011) identified FKBP12 as a novel regulator of Ras signaling through its modulation of depalmitoylation of H-Ras and its recycling from plasma membrane to the Golgi.
Liu, Jun O., Titov, Denis V., Dang, Yongjun, He, Qingli   +3 more
openaire   +2 more sources

Palmitoylation of the β4-Subunit Regulates Surface Expression of Large Conductance Calcium-activated Potassium Channel Splice Variants [PDF]

, 2013
Regulatory β-subunits of large conductance calcium- and voltage-activated potassium (BK) channels play an important role in generating functional diversity and control of cell surface expression of the pore forming α-subunits.
Bi, Danlei, Chen, Lie, Knaus, Hans Guenther, McClafferty, Heather, Ruth, Peter, Shipston, Michael J, Steeb, Franziska, Tian, Lijun   +7 more
core   +1 more source

Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration [PDF]

, 2022
Genetic CLN5 variants are associated with childhood neurodegeneration and Alzheimer’s disease; however, the molecular function of ceroid lipofuscinosis neuronal protein 5 (Cln5) is unknown.
Becker, Stefan, Bender, Daniel, Crowther, Lisa M, Erven, Ilka, Hofmann, Kai, Luebben, Anna, Steinfeld, Robert   +6 more
core   +1 more source

Palmitoylation in cardiometabolic diseases: From molecular mechanisms to clinical implications

Pharmacological Research
Cardiometabolic diseases (CMDs), encompassing both cardiovascular diseases and metabolic syndromes, are among the leading causes of global morbidity and mortality.
Shenghui Feng, Yue Zhou, Linjuan Guo, Yan Liang, Wengen Zhu   +4 more
doaj   +1 more source

Metabolic Labeling of Ras with Tritiated Palmitate to Monitor Palmitoylation and Depalmitoylation [PDF]

, 2013
Metabolic labeling with tritiated palmitate is a direct method for monitoring posttranslational modification of Ras proteins with this fatty acid. Advances in intensifying screens have allowed for the easy visualization of tritium without the need for extended exposure times.
Frederick D, Tsai, Joseph P, Wynne, Ian M, Ahearn, Mark R, Philips   +3 more
openaire   +2 more sources