Results 101 to 110 of about 10,903 (206)
Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond-Forming Non-ribosomal Peptide Synthetase Module [PDF]
, 2011 Cryptophycins (Crp) are a group of cyanobacterial depsipeptides with activity against drug-resistant tumors. Although they have been shown to be promising, further efforts are required to return these highly potent compounds to the clinic through a new ...
Bolduc, Kyle L. +4 more
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Synthesis of IB-01212 by multiple N-methylations of peptide bonds. [PDF]
, 2014 There are many natural peptides with multiple N-methylamino acids that exhibit potent attractive biological activities. N-methylation of a peptide bond(s) is also one of the standard approaches in medicinal chemistry of bioactive peptides, to improve the
Fujii, Nobutaka +4 more
core +1 more source
The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo.
PLoS Pathogens, 2015 UnlabelledPharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection.
Ole S Søgaard +18 more
doaj +1 more source
Human skin kinetics of cyclic depsipeptide mycotoxins [PDF]
, 2014 Cyclic depsipeptides (CDPs) are an emerging group of naturally occurring bioactive peptides, some of which are already developed as pharmaceutical drugs, e.g. valinomycin. They are produced by bacteria, marine organisms and fungi [1].
De Spiegeleer, Bart +3 more
core +1 more source
Digital PCR as a tool to measure HIV persistence [PDF]
, 2018 Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped.
Bosman, Kobus +4 more
core +1 more source
Molecules, 2017 The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled DOTA-TBIA101 imaging was performed in (NZR1) healthy rabbits; (NZR2)
Thomas Ebenhan +5 more
doaj +1 more source
Kinetik und Mechanismus der selektiven Bindung von Ionen durch Cyclodepsipeptid-Antibiotika
CHIMIA, 1972 Stability constants for cation complexes of valinomycin and enniatin B were determined in methanol employing spectrophotometric titrations. Kinetic studies by relaxation methods led to the elucidation of the reaction mechanism of complex formation ...
Th. Funck, F. Eggers, E. Grell
doaj +1 more source
Konformationsanalyse und Kinetik der Konformationsänderungen von membranaktiven Antibiotika
CHIMIA, 1972 Molecular properties of the membrane active antibiotics enniatin B, valinomycin and gramicidin A were investigated in various solvents. The conformational rearrangements of these antibiotics have been studied as a function of solvent polarity by ...
E. Grell, F. Eggers, Th. Funck
doaj +1 more source
Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo [PDF]
, 2017 The cyclooctadepsipeptide PF1022A derived from the fungus, Mycelia sterilia, is characterized by a broad spectrum of activity against different parasitic gastrointestinal nematodes of livestock.
HARDER, ACHIM +3 more
core
Pharmaceutics, 2018 Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance.
Ruba Malkawi +9 more
doaj +1 more source