Marine Organisms as a Prolific Source of Bioactive Depsipeptides [PDF]
Marine Drugs, 2023 Depsipeptides, an important group of polypeptides containing residues of hydroxy acids and amino acids linked together by amide and ester bonds, have potential applications in agriculture and medicine.
Mingyuan Zeng +4 more
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Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials [PDF]
Molecules, 2023 Cancer is currently considered one of the most threatening diseases worldwide. Diet could be one of the factors that can be enhanced to comprehensively address a cancer patient’s condition.
Plinio A. Trinidad-Calderón +2 more
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Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids [PDF]
Frontiers in Chemistry, 2023 Multicomponent reactions were performed to develop novel α,β-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, and quinolines.
Ricelia González +9 more
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Cyanobacterial Peptides in Anticancer Therapy: A Comprehensive Review of Mechanisms, Clinical Advances, and Biotechnological Innovation [PDF]
Marine DrugsCyanobacteria-derived peptides represent a promising class of anticancer agents due to their structural diversity and potent bioactivity. They exert cytotoxic effects through mechanisms including microtubule disruption, histone deacetylase inhibition ...
Heayyean Lee +2 more
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Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides [PDF]
BMC BiotechnologyBackground The Arctic environment, characterized by extreme conditions, hosts a largely untapped reservoir of fungal communities that have adapted to these harsh conditions by producing specialized bioactive secondary metabolites. Among these, Acremonium
Sailesh Maharjan +5 more
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Three New Depsipeptides, Homiamides A–C, Isolated from Streptomyces sp., ROA-065 [PDF]
MoleculesThree new depsipeptides, homiamides A–C (1–3), were isolated from a marine sediment-derived strain of Streptomyces sp., ROA-065. The planar structures of homiamides A–C (1–3) were elucidated using mass spectrometry (MS) and nuclear magnetic resonance ...
Jeong-Hyeon Kim +8 more
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Cytotoxic and Antibacterial Cyclodepsipeptides from an Endophytic Fungus Fusarium avenaceum W8 [PDF]
MoleculesSeven cyclic depsipeptides, including two new cyclic pentadepsipeptides avenamides A (1) and B (2), were isolated from a plant-derived fungus Fusarium avenaceum W8 by using the bioassay-guided fractionation method.
Zimo Wang +5 more
doaj +2 more sources
SynOpen, 2021 An efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions.
Hassan Farhid +3 more
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Peptides from Marine-Derived Fungi: Chemistry and Biological Activities
Marine Drugs, 2023 Marine natural products are well-recognized as potential resources to fill the pipeline of drug leads to enter the pharmaceutical industry. In this circumstance, marine-derived fungi are one of the unique sources of bioactive secondary metabolites due to
Salar Hafez Ghoran +4 more
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Synthesis and Biological Activities of Cyclodepsipeptides of Aurilide Family from Marine Origin
Marine Drugs, 2021 Aurilides are a class of depsipeptides occurring mainly in marine cyanobacteria. Members of the aurilide family have shown to exhibit strong cytotoxicity against various cancer cell lines.
Synthia Michon +2 more
doaj +1 more source