Results 11 to 20 of about 2,772 (159)
Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms
Marine Drugs, 2023 In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-
Wei Wang +7 more
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Life, 2022 The origin of biopolymers is a central question in origins of life research. In extant life, proteins are coded linear polymers made of a fixed set of twenty alpha-L-amino acids.
Moran Frenkel-Pinter +6 more
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Exploring the sequence space of unknown oligomers and polymers
Cell Reports Physical Science, 2021 Summary: The characterization of the chemistry of life on earth has been facilitated by developments in analysis and sequencing of bio-oligomers using tandem mass spectrometry (MS/MS).
David Doran +5 more
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A Survey of Didemnin Depsipeptide Production in Tistrella
Marine Drugs, 2023 As one of the first families of marine natural products to undergo clinical trials, the didemnin depsipeptides have played a significant role in inspiring the discovery of marine drugs.
Robert J. Stankey +4 more
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A Bidirectional Permeability Assay for beyond Rule of 5 Compounds
Pharmaceutics, 2021 Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involved ...
Yunhai Cui +6 more
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Marine Drugs, 2021 Marine actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the marine-derived Streptomyces sp.
Zhikai Guo +6 more
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A new depsipeptide antibiotic, citropeptin. [PDF]
Agricultural and Biological Chemistry, 1990 An actinomycete identified as Streptomyces flavidovirens was found to produce a new cyclic hexadepsipeptide antibiotic, designated citropeptin. Citropeptin showed antitumor activity against P388 murine leukemia.
Y, Hayakawa +3 more
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Total Syntheses of Colletopeptide A and Colletotrichamide A
Molecules, 2023 The first total syntheses of cyclic depsipeptides colletopeptide A and colletotrichamide A, have been accomplished. The key advanced intermediate, a cyclic tridepsipeptide derivative, was constructed using a sequence of transformations that features ...
Jing Chen +4 more
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Frontiers in Chemistry, 2020 Cyclic depsipeptides constitute a fascinating class of natural products. Most of them are characterized by an ester formed between the β-hydroxy function of Ser/Thr -and related amino acids- and the carboxylic group of the C-terminal amino acid.
Gerardo A. Acosta +14 more
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Total Synthesis of Pagoamide A
Molecules, 2021 The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous ...
Fusong Wu +4 more
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