Results 31 to 40 of about 2,772 (159)
Molecules, 2019 The first total syntheses of izenamides A, B, and C, which are depsipeptides inhibitor of cathepsin D, were accomplished. In addition, the stereochemistry of izenamide B was confirmed by our syntheses.
Changjin Lim
doaj +1 more source
Journal of Fungi, 2021 Fungi have been assured to be one of the wealthiest pools of bio-metabolites with remarkable potential for discovering new drugs. The pathogenic fungi, Fusarium oxysporum affects many valuable trees and crops all over the world, producing wilt.
Sabrin R. M. Ibrahim +4 more
doaj +1 more source
Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.A Golden Gate Assembly (GGA)‐based method was developed for the efficient assembly of natural and engineered non‐ribosomal peptide synthetases (NRPS). This method has enabled the creation of NRPS libraries to generate novel peptides in high‐throughput as well as the targeted derivatisation of natural products (NPs).
Adrian Podolski +7 more
wiley +2 more sources
Cyclic Octamer Peptoids: Simplified Isosters of Bioactive Fungal Cyclodepsipeptides
Molecules, 2018 Cyclic peptoids have recently emerged as an important class of bioactive scaffolds with unique conformational properties and excellent metabolic stabilities.
Assunta D’Amato +5 more
doaj +1 more source
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors
iScience, 2023 Summary: The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gαq/11 proteins. They are important pharmacological tools and have potential as therapeutic drugs.
Jan H. Voss +7 more
doaj +1 more source
Multicomponent synthesis of hydrazino depsipeptides [PDF]
RSC Advances, 2016 Multicomponent reactions (MCRs) offer numerous advantages over traditional sequential reactions for the synthesis of diverse structurally demanding compounds. Isocynide-based MCRs, particularly Passerini and Ugi reactions, are of special importance, because they provide peptide-like compounds able to mimic structure and/or function of natural peptides ...
Barić, Danijela, Jerić, Ivanka
openaire +3 more sources
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
In situ natural product discovery via an artificial marine sponge. [PDF]
PLoS ONE, 2014 There is continuing international interest in exploring and developing the therapeutic potential of marine-derived small molecules. Balancing the strategies for ocean based sampling of source organisms versus the potential to endanger fragile ecosystems ...
James J La Clair +5 more
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Frontiers in Molecular Biosciences, 2023 The Feature-based Molecular Networking (FBMN) is a well-known approach for mapping and identifying structures and analogues. However, in the absence of prior knowledge about the molecular class, assessing specific fragments and clusters requires time ...
Denise M. Selegato +4 more
doaj +1 more source
Total Synthesis of the Depsipeptide FR‐901375. [PDF]
ChemInform, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Yanping, Chen +4 more
openaire +2 more sources