Structural basis of chemokine interactions with heparan sulfate, chondroitin sulfate, and dermatan sulfate. [PDF]
J Biol Chem, 2019 Chemokines play diverse roles in human pathophysiology, ranging from trafficking leukocytes and immunosurveillance to the regulation of metabolism and neural function.
Sepuru KM, Rajarathnam K.
europepmc +4 more sources
Data in support for the measurement of heparan sulfate and dermatan sulfate by LC–MS/MS analysis [PDF]
Data in Brief, 2018 This article provides supplementary data for the paper “LC–MS/MS method for simultaneous quantification of heparan sulfate and dermatan sulfate in urine by butanolysis derivatization” (Forni et al., 2018).
Giulia Forni +8 more
doaj +3 more sources
Biological functions of iduronic acid in chondroitin/dermatan sulfate [PDF]
FEBS Journal, 2013 The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides because it generates a more flexible chain with increased binding potentials.
Martin A Thelin +2 more
exaly +3 more sources
The Dermatan Sulfate Proteoglycan Decorin Modulates α2β1 Integrin and the Vimentin Intermediate Filament System during Collagen Synthesis. [PDF]
PLoS ONE, 2012 Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling. Loss of the dermatan sulfate of decorin leads to an Ehlers-Danlos syndrome characterized by
Eckes, Beate +8 more
core +7 more sources
Comparative Study of Two Chondroitin Sulfate/Dermatan Sulfate 4-O-Sulfatases With High Identity [PDF]
Frontiers in Microbiology, 2019 Chondroitin sulfate/dermatan sulfate (CS/DS) sulfatases are potential tools for structural and functional studies of CD/DS chains. In our previous study, a CS/DS 4-O-endosulfatase (endoVB4SF) was identified from a marine bacterium (Wang et al., 2015 ...
Shumin Wang +6 more
doaj +3 more sources
Biosynthesis of Dermatan Sulfate [PDF]
Journal of Biological Chemistry, 2006 We identified the gene encoding chondroitin-glucuronate C5-epimerase (EC 5.1.3.19) that converts d-glucuronic acid to l-iduronic acid residues in dermatan sulfate biosynthesis. The enzyme was solubilized from bovine spleen, and an ∼43,000-fold purified preparation containing a major 89-kDa candidate component was subjected to mass spectrometry analysis
Marco Maccarana +7 more
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Effect of epithelial debridement on human cornea proteoglycans [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
doaj +2 more sources
Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis. [PDF]
PLoS ONE, 2015 The epimerization of glucuronic acid into iduronic acid adds structural variability to chondroitin/dermatan sulfate polysaccharides. Iduronic acid-containing domains play essential roles in processes such as coagulation, chemokine and morphogen ...
Xanthi N Stachtea +6 more
doaj +2 more sources
Preparation and purification of Flavobacterium heparinum chondroitinases AC and B by hydrophobic interaction chromatography [PDF]
Brazilian Journal of Medical and Biological Research, 1999 Flavobacterium heparinum is a soil bacterium that produces several mucopolysaccharidases such as heparinase, heparitinases I and II, and chondroitinases AC, B, C and ABC. The purpose of the present study was to optimize the preparation of F.
J.A.K. Aguiar, Y.M. Michelacci
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