Effect of epithelial debridement on human cornea proteoglycans [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
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Preparation and purification of Flavobacterium heparinum chondroitinases AC and B by hydrophobic interaction chromatography [PDF]
Brazilian Journal of Medical and Biological Research, 1999 Flavobacterium heparinum is a soil bacterium that produces several mucopolysaccharidases such as heparinase, heparitinases I and II, and chondroitinases AC, B, C and ABC. The purpose of the present study was to optimize the preparation of F.
J.A.K. Aguiar, Y.M. Michelacci
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Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. [PDF]
PLoS Genetics, 2018 Gerodermia osteodysplastica (GO) is characterized by skin laxity and early-onset osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of poorly characterized function.
Wing Lee Chan +22 more
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Glycosaminoglycan distribution in the rat uterine cervix during the estrous cycle [PDF]
Clinics, 2010 OBJECTIVE: To analyze the amount of glycosaminoglycans in the uterine cervix during each phase of the rat estrous cycle. DESIGN: Based on vaginal smears, forty female, regularly cycling rats were divided into four groups (n = 10 for each group): GI ...
Jairo Jose Matozinho Cubas +5 more
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Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors [PDF]
Brazilian Journal of Medical and Biological Research, 2003 Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled by specific inhibitors and may be ...
Gozzo A.J. +7 more
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Journal of Biological Chemistry, 1968 Abstract The properties of dermatan sulfate, isolated from umbilical cord, have been compared with those of pig skin dermatan sulfate. Like the latter polysaccharide, umbilical cord dermatan sulfate was found to be a hybrid containing both l-iduronic and d-glucuronic acid; whereas the galactosamine units of pig skin dermatan sulfate were exclusively 4 ...
L Å Fransson
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Journal of Biological Chemistry, 1967 Abstract The presence of d-glucuronic acid in dermatan sulfate preparations has previously been reported from several laboratories. It has not been clear whether the d-glucuronic acid represents a contamination with another polymer or whether it is actually part of the dermatan sulfate molecule.
Lars‐Âke Fransson, Lennart Rodén
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The Interaction between Chondroitin Sulfate and Dermatan Sulfate Tetrasaccharides and Pleiotrophin. [PDF]
Int J Mol Sci, 2022 Pleiotrophin (PTN) is a neurotrophic factor that participates in the development of the embryonic central nervous system (CNS) and neural stem cell regulation by means of an interaction with sulfated glycosaminoglycans (GAGs). Chondroitin sulfate (CS) is the natural ligand in the CNS.
García-Jiménez MJ +3 more
europepmc +5 more sources
Chondroitin Sulfate/Dermatan Sulfate-Protein Interactions and Their Biological Functions in Human Diseases: Implications and Analytical Tools. [PDF]
Front Cell Dev Biol, 2021 Zhang B, Chi L.
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Modular automated solid phase synthesis of dermatan sulfate oligosaccharides [PDF]
, 2014 Dermatan sulfates are glycosaminoglycan polysaccharides that serve a multitude of biological roles as part of the extracellular matrix. Orthogonally protected D-galactosamine and L-iduronic acid building blocks and a photo- cleavable linker are ...
Jeyakumar Kandasamy +4 more
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