Modular automated solid phase synthesis of dermatan sulfate oligosaccharides [PDF]
Chemical Communications, 2014 Dermatan sulfates are glycosaminoglycan polysaccharides that serve a multitude of biological roles as part of the extracellular matrix. Orthogonally protected D-galactosamine and L-iduronic acid building blocks and a photo- cleavable linker are ...
Hahm, Heung Sik +4 more
core +2 more sources
Dermatan Sulfate: Structure, Biosynthesis, and Biological Roles [PDF]
BiomoleculesDermatan sulfate (DS) is a remarkably versatile glycosaminoglycan that plays critical roles across a wide array of biological processes. Its unique structure, characterized by repeating disaccharide units of N-acetyl-D-galactosamine (GalNAc) and Iduronic
Congcong Chen +7 more
doaj +2 more sources
Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration. [PDF]
PLoS ONE, 2011 As C-Xyloside has been suggested to be an initiator of glycosaminoglycan (GAG) synthesis, and GAGs such as Dermatan sulfate (DS) are potent enhancers of fibroblast growth factor (FGF)--10 action, we investigated if a C-Xylopyranoside derivative, (C-β-D ...
Jun Muto +5 more
doaj +2 more sources
Glycosaminoglycan distribution in the rat uterine cervix during the estrous cycle [PDF]
Clinics, 2010 OBJECTIVE: To analyze the amount of glycosaminoglycans in the uterine cervix during each phase of the rat estrous cycle. DESIGN: Based on vaginal smears, forty female, regularly cycling rats were divided into four groups (n = 10 for each group): GI ...
Jairo Jose Matozinho Cubas +5 more
doaj +7 more sources
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. [PDF]
PLoS Genetics, 2018 Gerodermia osteodysplastica (GO) is characterized by skin laxity and early-onset osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of poorly characterized function.
Wing Lee Chan +22 more
doaj +7 more sources
Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan
International Journal of Cell Biology, 2013 As most proteoglycans exert their biological activities in the pericellular region, circulating Endocan has appeared since its discovery as an atypical dermatan sulfate proteoglycan, with distinctive structural and functional properties.
Maryse Delehedde
exaly +2 more sources
Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors [PDF]
Brazilian Journal of Medical and Biological Research, 2003 Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled by specific inhibitors and may be ...
Gozzo A.J. +7 more
doaj +2 more sources
Characterization of the interaction of interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated derivatives by spectroscopy and molecular modeling [PDF]
Glycobiology, 2011 The interactions between glycosaminoglycans (GAGs), important components of the extracellular matrix, and proteins such as growth factors and chemokines play critical roles in cellular regulation processes.
Annelie Pichert +8 more
semanticscholar +2 more sources
Evaluating Chondroitin Sulfate and Dermatan Sulfate Expression in Glial Scar to Determine Appropriate Intervention Time in Rats [PDF]
Basic and Clinical Neuroscience, 2020 Introduction: The proteoglycans of the extracellular matrix increases in the glial scar during spinal cord injury and significantly affects the inhibition of axonal regeneration.
Sara Rezaei +5 more
doaj +2 more sources
Composition and Anticoagulant Potential of Chondroitin Sulfate and Dermatan Sulfate from Inedible Parts of Garfish (Belone belone). [PDF]
Foods, 2023 Chikha SB +8 more
europepmc +3 more sources