Results 51 to 60 of about 8,483 (198)
Biosynthesis of Dermatan Sulfate [PDF]
Journal of Biological Chemistry, 2006 We identified the gene encoding chondroitin-glucuronate C5-epimerase (EC 5.1.3.19) that converts D-glucuronic acid to L-iduronic acid residues in dermatan sulfate biosynthesis. The enzyme was solubilized from bovine spleen, and an approximately 43,000-fold purified preparation containing a major 89-kDa candidate component was subjected to mass ...
Maccarana, Marco +7 more
openaire +5 more sources
Extracellular matrix alterations in the Peyronie’s disease
Journal of Advanced Research, 2017 Peyronie’s disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim of the present study was to investigate alterations in the extracellular matrix in Peyronie’s disease.
Marcelo Silva Watanabe +8 more
doaj +1 more source
Protein glycosylation in lung cancer from a mass spectrometry perspective
Mass Spectrometry Reviews, EarlyView.Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi +2 more
wiley +1 more source
Collagens and proteoglycans of the corneal extracellular matrix
Brazilian Journal of Medical and Biological Research, 2003 The cornea is a curved and transparent structure that provides the initial focusing of a light image into the eye. It consists of a central stroma that constitutes 90% of the corneal depth, covered anteriorly with epithelium and posteriorly with ...
Y.M. Michelacci
doaj +1 more source
Frontiers in Microbiology, 2022 Chondroitin sulfate (CS)/dermatan sulfate (DS) is a kind of sulfated polyanionic, linear polysaccharide belonging to glycosaminoglycan. CS/DS sulfatases, which specifically hydrolyze sulfate groups from CS/DS oligo-/polysaccharides, are potential tools ...
Lin Wei +10 more
doaj +1 more source
The FEBS Journal, EarlyView.Interactions between bacteria and the extracellular matrix are a prerequisite for colonisation and infection. Phylogenetically diverse M proteins of group A Streptococcus (GAS) can selectively bind sulfated glycosaminoglycans with high affinity. M protein‐mediated recruitment of chondroitin sulfate and dermatan sulfate was shown to increase GAS ...
Tahnee B.‐D. McEwan +8 more
wiley +1 more source
Galactosaminoglycan Function and Oligosaccharide Structure Determination
The Scientific World Journal, 2007 This review will discuss the importance of sequencing long chondroitin sulfate and dermatan sulfate chains specifically derived from decorin. Decorin is a member of the small leucine-rich repeat proteoglycans and ubiquitously expressed primarily in the ...
Daniela G. Seidler +2 more
doaj +1 more source
Sulodexide: implicazioni cliniche ed economiche
Farmeconomia: Health Economics and Therapeutic Pathways, 2005 Sulodexide is a highly purified glycosaminoglycan approved for leg ulcers treatment. It contains two principal components: heparan sulfate, a fast-moving heparin fraction, (80%) and dermatan sulfate (20%).
Orietta Zaniolo, Mario Eandi
doaj +1 more source
Diversity and development of the hemibacula of croaking geckos (Sphaerodactylidae: Aristelliger)
Journal of Anatomy, EarlyView.Geckos in the genus Aristelliger exhibit enigmatic mineralized elements in their hemipenes, called hemibacula. We examined hemibacula of every species of Aristelliger using μCT, clearing and staining, and histology. We found hemibacula exhibit lineage‐specific morphology, isometric growth after sexual maturity, and are composed of mineralized ...
Aaron H. Griffing +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Endothelial specific molecule‐1 (ESM‐1) and guanylate binding protein‐1 (GBP‐1) are proteins that are produced by activated/dysfunctional endothelial cells and are increased and decreased, respectively, during preeclampsia. It remains to be established whether ESM‐1 and GBP‐1 could potentially be included as biomarkers for the ...
Ines Pronk +3 more
wiley +1 more source