c-Src/Cav1-dependent activation of the EGFR by Dsg2. [PDF]
, 2016 The desmosomal cadherin, desmoglein 2 (Dsg2), is deregulated in a variety of human cancers including those of the skin. When ectopically expressed in the epidermis of transgenic mice, Dsg2 activates multiple mitogenic signaling pathways and increases ...
Brennan-Crispi, Donna M. +8 more
core +2 more sources
Human Meningiomas Reveal No Evidence of Neuroendocrine Differentiation
APMIS, Volume 134, Issue 3, March 2026.ABSTRACT Meningiomas are heterogeneous tumors and studies suggest that meningiomas might be part of MEN1 syndrome. The tumors express somatostatin receptors (SSTRs) comparable to that seen in neuroendocrine neoplasms. We aimed to explore neuroendocrine differentiation in meningiomas by investigating the following neuroendocrine markers: neural cell ...
Sofie Eline Tollefsen +7 more
wiley +1 more source
A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders
Experimental Dermatology, Volume 35, Issue 3, March 2026.ABSTRACT Ankyloblepharon‐ectodermal defects‐cleft lip/palate (AEC) is a disorder caused by autosomal‐dominant mutations in the TP63 gene. AEC is characterised by the presence of severe and painful skin erosions that can take years to heal. Current treatment options for these devastating lesions are limited, highlighting the need for new therapeutic ...
Maddison N. Salois +4 more
wiley +1 more source
Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations [PDF]
, 2016 Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death.
Benítez Iglesias, Raúl +14 more
core +2 more sources
Frontiers in Physiology, 2012 Arrhythmogenic right ventricular cardiomyopathy and Brugada syndrome are distinct clinical entities which diagnostic criteria exclude their coexistence in individual patients.
Mark eHoogendijk, Mark eHoogendijk
doaj +1 more source
Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolution [PDF]
, 2018 Transmission electron microscopy has provided most of what is known about the ultrastructural organization of tissues, cells, and organelles. Due to tremendous advances in crystallography and magnetic resonance imaging, almost any protein can now be ...
Chiquet, Matthias +2 more
core
Diversity of Intercellular Communication Modes: A Cancer Biology Perspective
CellsFrom the moment a cell is on the path to malignant transformation, its interaction with other cells from the microenvironment becomes altered. The flow of molecular information is at the heart of the cellular and systemic fate in tumors, and various ...
Thanzeela Ebrahim +2 more
doaj +1 more source
Ultrastructure of the microfilaria of Brugia pahangi (Buckley and Edeson, 1956) Buckley, 1958 [PDF]
, 1977 The microfilaria of Brugia pahangi obtained from an experimentally infected dog were observed with the electron microscope. The sheath was composed of small granules and was covered with electron-dense particles on the outer surface and with small ...
Suguri, Setsuo
core +1 more source
Dsg2 ectodomain organization increases throughout desmosome assembly
Cell Adhesion & MigrationDesmosomes are intercellular junctions that regulate mechanical integrity in epithelia and cardiac muscle. Dynamic desmosome remodeling is essential for wound healing and development, yet the mechanisms governing junction assembly remain elusive.
William F. Dean +5 more
doaj +1 more source
Evaluation of Genetic Causes of Cardiomyopathy in Childhood [PDF]
, 2015 Cardiomyopathy frequently has a genetic basis. In adults, mutations in genes encoding components of the sarcomere, cytoskeleton, or desmosome are frequent genetic causes of cardiomyopathy.
Ware, Stephanie M.
core +1 more source