Results 71 to 80 of about 16,875 (201)

European S2k guidelines on management of autoimmune blistering diseases in children and adolescents

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Autoimmune blistering disorders (AIBDs) in children are rare, challenging to diagnose and treat and often require immunosuppressants. Until now, no paediatric care guidelines existed. The EADV Task Force for AIBDs has developed the consensus‐based recommendations, enabling physicians to adopt a uniform, tailored treatment strategy to improve outcomes ...
A. Nanda, B. Tedbirt, C. Bodemer, M. C. Bolling, M. El Hachem, M. Nikolić, E. Benton, M. Caproni, D. De, D. Didona, K. Drenovska, M. Goebeler, M. Hertl, B. Horváth, M. Kasperkiewicz, D. Kiritsi, M. Larralde, A. V. Marzano, J. Meijer, D. F. Murrell, J. Powell, E. Sprecher, N. S. Chandran, M. M. Tomayko, S. Uzun, N. van Beek, H. Ott, A. Patsatsi, A. Torrelo, A. Welfringer‐Morin, E. Schmidt, P. Joly   +31 more
wiley   +1 more source

Gene expression differs in susceptible and resistant amphibians exposed to Batrachochytrium dendrobatidis. [PDF]

, 2018
Chytridiomycosis, the disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has devastated global amphibian biodiversity. Nevertheless, some hosts avoid disease after Bd exposure even as others experience near-complete extirpation ...
Eskew, Evan A, Foley, Janet E, Keel, Kevin, LaDouceur, Elise EB, Miller, Michael R, Shock, Barbara C, Todd, Brian D   +6 more
core   +2 more sources

Reconstruction of native cellular microanatomy in a novel bioengineered full thickness human nasal mucosal construct

Journal of Anatomy, EarlyView.
Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury, Bethany Dickson, Nicola Curtis, David Bunton, Kirsty Goncalves, Stefan Przyborski   +5 more
wiley   +1 more source

Proper autophagy is indispensable for angiogenesis during chick embryo development [PDF]

, 2016
People have known that autophagy plays a very important role in many physiological and pathological events. But autophagy role on embryonic angiogenesis still remains obscure.
Cao, Liu, Chuai, Manli, Liu, Langxia, Lu, Wen-hui, Ma, Zheng-lai, Munsterberg, Andrea, Shi, Yu-xun, Song, Xiaoyu, Wang, Guang, Yang, Xuesong   +9 more
core   +2 more sources

Erythrokeratodermia‐Cardiomyopathy Syndrome: Expanding the DSP Mutational Spectrum Beyond Proline Substitutions

Pediatric Dermatology, EarlyView.
ABSTRACT Erythrokeratodermia cardiomyopathy (EKC) syndrome is a rare autosomal dominant disorder characterized by generalized erythrokeratoderma and progressive dilated cardiomyopathy, caused by pathogenic variants in the SR6 domain of desmoplakin (DSP).
Sepideh Hamzehlou, Ryland D. Mortlock, Caroline Echeandia‐Francis, Jing Zhou, Chao Xing, Nnenna G. Agim, Keith A. Choate, Donald A. Glass II   +7 more
wiley   +1 more source

Arrhythmogenic Cardiomyopathy: Molecular Insights for Improved Therapeutic Design

Journal of Cardiovascular Development and Disease, 2020
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by structural and electrical cardiac abnormalities, including myocardial fibro-fatty replacement.
Tyler L. Stevens, Michael J. Wallace, Mona El Refaey, Jason D. Roberts, Sara N. Koenig, Peter J. Mohler   +5 more
doaj   +1 more source

Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells

Cells, 2023
The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 ...
Hong Wan, Muy-Teck Teh, Giulia Mastroianni, Usama Sharif Ahmad   +3 more
doaj   +1 more source

Oral wound healing in the elderly: Mechanisms, challenges, and innovations

Periodontology 2000, EarlyView.
Abstract Objective This narrative synthesizes current knowledge on the biological mechanisms, clinical challenges, and regenerative innovations for optimizing intraoral wound healing in the elderly. Methods Narrative review of preclinical and clinical studies addressing age‐related changes in the four canonical wound‐healing phases (hemostasis ...
Ann M. Decker, Sandra H. Stuhr, Gustavo Avila‐Ortiz, Andrea Pilloni, Lorenzo Marini, Rogerio Castilho, Beth I. Wallace, Yvonne L. Hernandez‐Kapila   +7 more
wiley   +1 more source

Atomic Force Microscopy Provides New Mechanistic Insights into the Pathogenesis of Pemphigus

Frontiers in Immunology, 2018
Autoantibodies binding to the extracellular domains of desmoglein (Dsg) 3 and 1 are critical in the pathogenesis of pemphigus by mechanisms leading to impaired function of desmosomes and blister formation in the epidermis and mucous membranes. Desmosomes
Franziska Vielmuth, Volker Spindler, Jens Waschke   +2 more
doaj   +1 more source

Cryo-EM Structure of Functional BK Channels in Lipid Bilayers [PDF]

, 2004
It has already widely been shown that the extension of the urban space takes a polycentric shape: suburban employment sub-centres emerge. The objective in this study is to measure employment concentrations inside and around urban agglomerations and to ...
Ann Verhetsel, Haike Van Dyck, Isabelle Thomas, Marc Servais   +3 more
core   +1 more source