Diastereoselective Spiroannulation of Phenolic Substrates: Advances Towards the Asymmetric Formation of the Manumycin m-C7N Core Skeleton [PDF]
Molecules, 2007 The asymmetric syntheses of two new spirolactones prepared in optically pure form from L-3-nitrotyrosine are described. The key step, an oxidative spiroannulation, was carried out on the optically active phenols 11a and 11b and afforded the new ...
Thomas W. Scully +3 more
doaj +2 more sources
Highly Diastereoselective Synthesis of Spiropyrazolones [PDF]
Molecules, 2015 We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
Victor Ceban +3 more
doaj +5 more sources
Diastereoselective Intramolecular Cyanoamidation with Alkenes [PDF]
European Journal of Organic Chemistry, 2016 Reported herein is a diastereoselective intramolecular alkene cyanoamidation, wherein high d.r. values are imparted by chiral directing groups. Lactams with an α‐all‐carbon quaternary stereocenter are readily synthesized, which may enable access to structures frequently found in biologically active molecules and natural products.
Ashley M. Dreis +5 more
openaire +3 more sources
Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization
Nature Communications, 2016 Using a chiral catalyst to override the innate stereochemical outcome of a diastereoselective process is a challenging task. Here, the authors use theory and experiment to develop a cycloisomerization where the enantioselectivity is driven by the ...
R. N. Straker +4 more
doaj +2 more sources
Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes [PDF]
Nature CommunicationsAlthough chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrate-induced ...
Jiaming Wang +4 more
doaj +2 more sources
Enantio‐ and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis
Angewandte Chemie, 2021 We report an enantio‐ and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one‐pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces ...
Daniel Moock +4 more
semanticscholar +1 more source
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives
Molecules, 2021 Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the ...
Aitor Maestro +5 more
doaj +1 more source
Phytophenol Dimerization Reaction: From Basic Rules to Diastereoselectivity and Beyond
Molecules, 2022 Phytophenol dimerization, which is a radical-mediated coupling reaction, plays a critical role in many fields, including lignin biosynthesis. To understand the reaction, 2,2-diphenyl-1-picrylhydrazyl radical was used to initiate a series of phytophenol ...
Shuqin Liu +5 more
doaj +1 more source
Diastereoselective 1,3-nitrooxygenation of bicyclo[1.1.0]butanes. [PDF]
Chem SciMaity A +3 more
europepmc +3 more sources
Molecules, 2022 The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction ...
Amarender Manchoju +8 more
doaj +1 more source