Highly Diastereoselective Synthesis of Spiropyrazolones [PDF]
Molecules, 2015 We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
Victor Ceban +3 more
doaj +6 more sources
Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes [PDF]
Nature CommunicationsAlthough chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrate-induced ...
Jiaming Wang +4 more
doaj +2 more sources
Diastereoselective Hydrogenation in the Preparation of Fine Chemicals [PDF]
Topics in Catalysis, 2018 Heterogeneous catalytic diastereoselective hydrogenation is reviewed with a special emphasis on its application in the preparation of fine ...
Kukula, Pavel, Prins, Roel
core +6 more sources
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives
Molecules, 2021 Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the ...
Aitor Maestro +5 more
doaj +1 more source
Molecules, 2022 The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction ...
Amarender Manchoju +8 more
doaj +1 more source
Phytophenol Dimerization Reaction: From Basic Rules to Diastereoselectivity and Beyond
Molecules, 2022 Phytophenol dimerization, which is a radical-mediated coupling reaction, plays a critical role in many fields, including lignin biosynthesis. To understand the reaction, 2,2-diphenyl-1-picrylhydrazyl radical was used to initiate a series of phytophenol ...
Shuqin Liu +5 more
doaj +1 more source
Diastereoselective Formation of trans-HC(O)SH Through Hydrogenation of OCS on Interstellar Dust Grains [PDF]
, 2021 With the presence of evermore complex S-bearing molecules being detected lately, studies on their chemical formation routes need to keep up the pace to rationalize observations, suggest new candidates for detection, and provide input for chemical evolution models.
arxiv +1 more source
Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives [PDF]
, 2005 Background: Many polyhydroxylated piperidines are inhibitors of the oligosaccharide processing enzymes, glycosidases and glycosyltransferases. Aza-C-linked disaccharide mimetics are compounds in which saturated polyhydroxylated nitrogen and oxygen ...
Adam Nelson +8 more
core +3 more sources
Diastereoselective Synthesis of Benzoxanthenones
Chemistry – An Asian Journal, 2020 AbstractAn oxidative catalytic vanadium(V) system was developed to access the naturally nonabundant diastereomers of carpanone from the corresponding alkenyl phenol monomer in one pot by tandem oxidation, oxidative coupling, and 4+2 cyclization. This system was applied to the synthesis of two other analogues of carpanone.
William C. Neuhaus, Marisa C Kozlowski
openaire +4 more sources
Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-didehydroxyisogarcinol and (±)-6,30-epi-garcimultiflorone A utilizing highly diastereoselective, Lewis acid-controlled cyclizations [PDF]
, 2016 The first syntheses of 13,14-didehydroxyisogarcinol (6) and garcimultiflorone A (5) stereoisomers are reported in six steps from a commercially available phloroglucinol.
Boyce, Jonathan H. +2 more
core +1 more source