Results 41 to 50 of about 83,038 (344)

Novel Sulfonium Reagents for the Modular Synthesis of Spiro[2.3]Hexanes and Heteroatom‐Containing Analogues: Synthesis, Application, and Evaluation as Bioisosteres

Angewandte Chemie, EarlyView.
Strained spirocyclic spiro[2.3]hexane and its heteroatom‐containing derivatives, including previously underrepresented 5‐oxa‐1‐azaspiro[2.3]hexanes and 1,5‐diazaspiro[2.3]hexanes, were synthesized via a modular approach of insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into alkenes, carbonyls and imines.
Philipp Natho, Annarita Vicenti, Fabrizio Mastrolorito, Francesca De Franco, Lee Walsh‐Benn, Marco Colella, Ernesto Mesto, Emanuela Schingaro, Orazio Nicolotti, Antimo Gioiello, Renzo Luisi   +10 more
wiley   +2 more sources

(1R/S,7aS/R)-1-Benzyl-1-[2,8-bis(trifluoromethyl)quinolin-4-yl]-hexahydro-oxazolo[3,4-a]pyridin-3-one

Molbank, 2023
An unexpected diastereoselective C-alkylation of a mefloquine derivative in up to 57% yield was the result of an attempted Williamson etherification of Boc-mefloquine.
Dawid J. Kucharski, Przemysław J. Boratyński   +1 more
doaj   +1 more source

Diastereoselective and Enantioselective Conjunctive Cross-Coupling Enabled by Boron Ligand Design.

Journal of the American Chemical Society, 2018
Enantio- and diastereoselective conjunctive cross-coupling of β-substituted alkenylboron "ate" complexes is studied. Whereas β-substitution shifts the chemoselectivity of the catalytic reaction in favor of the Suzuki-Miyaura product, use of a boronic ...
Jesse A. Myhill, Christopher A Wilhelmsen, Liang Zhang, J. Morken   +3 more
semanticscholar   +1 more source

Stereodivergent Synthesis of Three Contiguous Stereogenic Centers by Cu/Ir‐Catalyzed Borylallylation

Angewandte Chemie, EarlyView.
An alkene borylallylation strategy enabled by cooperative Cu/Ir‐catalysis has been uncovered for accessing three contiguous stereogenic centres. This strategy is notable given the inherent challenges of constructing molecules with multiple stereocenters while maintaining high selectivity bearing diverse functional groups.
Suman Das, Stanna K. Dorn, M. Kevin Brown   +2 more
wiley   +2 more sources

Diastereoselective synthesis of 3,4-dihydro-2H-pyran-4-carboxamides through an unusual regiospecific quasi-hydrolysis of a cyano group

Beilstein Journal of Organic Chemistry, 2016
An efficient diastereoselective approach for the synthesis of functionalized 3,4-dihydro-2H-pyran-4-carboxamides with variable frame was developed based on the reaction of available 4-oxoalkane-1,1,2,2-tetracarbonitriles (adducts of TCNE and ketones ...
Mikhail Yu. Ievlev, Oleg V. Ershov, Mikhail Yu. Belikov, Angelina G. Milovidova, Viktor A. Tafeenko, Oleg E. Nasakin   +5 more
doaj   +1 more source

Synthesis of Enantiopure Oxygen- and Nitrogen-Containing Heterocycles by Diastereoselective Ring-Closing Metathesis Reaction in Perhydro-1,3-benzoxazine Derivatives [PDF]

, 2019
Producción CientíficaDiastereoselective ring‐closing metathesis reactions on chiral trienic perhydro‐1,3‐benzoxazines derived from (−)‐8‐aminomenthol featuring two diastereotopic olefin chains is described.
Andrés Juan, Celia, Gutiérrez Loriente, Agustín, Martín Álvarez, José Miguel, Nieto Román, Francisco Javier, Prieto, Elena   +4 more
core   +2 more sources

Diastereoselective Construction of Indole-Bridged Chroman Spirooxindoles through a TfOH-Catalyzed Michael Addition-Inspired Cascade Reaction.

Journal of Organic Chemistry, 2018
The first highly diastereoselective Michael addition/condensation/Friedel-Crafts alkylation cascade reaction of 3-indolyl-substituted oxindoles with ortho-hydroxychalcones was established, which afforded a wide range of polycyclic indole-bridged chroman ...
Jiaomei Guo, Xuguan Bai, Qilin Wang, Zhanwei Bu   +3 more
semanticscholar   +1 more source

A Radical Cascade with Double Intramolecular Hydrogen Atom Transfer for the Generation of Bisfunctionalized Cyclopentanes from Linear Alkynes

Angewandte Chemie, EarlyView.
A radical cascade process involving the activation of two aliphatic C–H bonds in a series of five elementary steps converts readily available terminal alkynes into functionalized cyclopentylmethyl arylsulfones. The methodology delivers flexible synthetic intermediates and was applied to the preparation of diquinanes and triquinanes possessing a rare ...
Lise Benoist, Éléonore Barbier, Mariam Sangare, Philippe Renaud, Fabrice Dénès   +4 more
wiley   +2 more sources

Stereoselective Synthesis of 4-O-Tosyltetrahydropyrans via Prins Cyclization Reaction of Enol Ethers

SynOpen, 2019
Intramolecular cyclization of enol ethers mediated by para-toluenesulfonic acid leads to substituted tetrahydropyrans in good to moderate yields. The reaction is diastereoselective.
Sujit Sarkar, Namita Devi, Bikoshita Porashar, Santu Ruidas, Anil K Saikia   +4 more
doaj   +1 more source

A Diastereoselective Synthetic Approach towards the Synthesis of Berkeleylactone F and Its 4-epi-Derivative

SynOpen, 2020
A diastereoselective approach to the synthesis of berkeleylactone F is presented. The synthetic strategy is initiated with commercially available (R)-glycidol, 1,6-heptadiyne, and (R)-(+)-methyl lactate.
Srijana Subba, Sumit Saha, Susanta Mandal   +2 more
doaj   +1 more source