An Efficient One-Pot Three-Component Synthesis of Fused 1,4-Dihydropyridines Using HY-Zeolit
Molecules, 2009 A facile and convenient protocol was developed for the fast (2.5-3.5 h) and high yielding (70-90 %) synthesis of fused 1,4-dihydropyridines from dimedone in the presence of HY-zeolite as an efficient recyclable heterogeneous catalyst.
Khalil Tabatabaeian +2 more
doaj +3 more sources
Adenosine modulators and calcium channel blockers as add-on treatment for schizophrenia
npj Schizophrenia, 2021 Relapses remain common among individuals with schizophrenia indicating a need for improved treatments. Creating a completely new drug molecule is expensive and time consuming, and therefore drug repurposing should be considered.
Jonne Lintunen +4 more
doaj +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2012 We have developed a general synthesis of polysubstituted 1,4-dihydropyridines and pyridines based on a highly regioselective lithiation/6-endo-dig intramolecular carbolithiation from readily available N-allyl-ynamides.
Wafa Gati +3 more
doaj +1 more source
An In-Depth Examination of Formularies and Other Features of Medicare Drug Plans [PDF]
, 2006 Provides a detailed assessment of the formularies, drug costs, and utilization management tools offered by the fourteen nationwide organizations that account for most of the stand-alone prescription drug ...
Elizabeth Hargrave +3 more
core
Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes [PDF]
The prototype 1,4-dihydropyridine (1,4-DHP) nifedipine, indicated for the management of hypertension and angina pectoris, has drawbacks of rapid onset of vasodilating action and a short half-life.
Baarnhielm +15 more
core +1 more source
Diethyl 2,6-Dimethyl-4-(naphthalen-1-yl)-1,4-Dihydropyridine-3,5-Dicarboxylate [PDF]
, 2016 In the title compound, C23H25NO4, the 1,4-dihydropyridine ring adopts a flattened boat conformation. The naphthalene ring system forms a dihedral angle of 88.59 (6)° with the pyridine ring.
Noor Shahina Begum, ., Prasad, N.L.
core +1 more source
Clinical Advantages of Lipophilic Dihydropyridines
Blood Pressure, 1998 Lipophilic dihydropyridines have many theoretical and practical clinical advantages owing to their long permanence at the cell membrane. They have a greater chance of smoothly and permanently reducing blood pressure over 24 h than other dihydropyridines, a feature that may have positive prognostic implications since 24-h blood pressure is more closely ...
G, Mancia, S, Omboni, A, Zanchetti
openaire +2 more sources
Reactions of biologically inspired hydride sources with B(C6F5)3 [PDF]
, 2017 The combination of 1-benzyl-1,4-dihydropyridines with the strong Lewis acid, B(C6F5)3, generates a stable pyridinium borohydride species in high yields (94%) in as little as 10 min.
Luk, Louis Y. P. +3 more
core +1 more source
Green and Regioselective Approach for the Synthesis of 3-Substituted Indole Based 1,2-Dihydropyridine and Azaxanthone Derivatives as a Potential Lead for SARS-CoV-2 and Delta Plus Mutant Virus: DFT and Docking Studies [PDF]
, 2022 Jayabal Kamalraja +6 more
openalex +1 more source