MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms [PDF]
JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, “For as a candle burns much faster
Buckler, Keith J. +3 more
core
Aim. The TOLERANCE study was aimed to compare the tolerability of high doses of lercanidipine (20 mg) with that of other frequently used dihydropyridines (amlodipine 10 mg/nifedipine GITS 60 mg) in the treatment of essential hypertension (EAH) in daily ...
V. Barrios +6 more
doaj
Catalytic Intermolecular Hetero-Dehydro-Diels–Alder Cycloadditions: Regio- and Diasteroselective Synthesis of 5,6-Dihydropyridin-2-ones [PDF]
A novel catalyzed intermolecular heterodehydro-Diels–Alder reaction between push–pull 1,3-dien-5-ynes and aldimines or silylaldimines is reported.
Aguilar, Enrique +2 more
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Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process
A Brønsted acidic ionic liquid, 3-(N,N-dimethyldodecylammonium) propanesulfonic acid hydrogen sulphate ([DDPA][HSO4]), has been successfully applied to catalyze sequential oxidation of aromatic alcohols with NaNO3 followed by their condensation with ...
Xiaobing Liu, Bin Liu
doaj +1 more source
Komplexchemie perhalogenierter Cyclopentadiene und Alkine, VII [PDF]
Coordination Chemistry of Perhalogenated Cyclopentadienes and Alkynes, VII1). - Synthesis of Several Tetrachlorometalloles of Cobalt, Rhodium, and Iridium; Structure of a Iridacyclopentadiene Derivative The reaction of dichloroethyne with CpCo(PPh3)2 ...
Clarke +15 more
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Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates
The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions.
Brigita Vigante +9 more
doaj +1 more source
Electrophysiological effects of 5-hydroxytryptamine on isolated human atrial myocytes, and the influence of chronic beta-adrenoceptor blockade [PDF]
<b>1.</b> 5-Hydroxytryptamine (5-HT) has been postulated to play a proarrhythmic role in the human atria via stimulation of 5-HT<sub>4</sub> receptors.
Andrew C Rankin +32 more
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Naloxone inhibits nicotine-induced receptor current and catecholamine secretion in bovine chromaffin cells [PDF]
Nicotine-induced catecholamine (CA) secretion and inward ionic currents were inhibited by the opioid antagonist naloxone in cultured bovine chromaffin cells.
Ceña, Valentín +4 more
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Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]
In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S. +3 more
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