Results 1 to 10 of about 691,511 (145)
Biomolecules, 2021 DNA in our cells is constantly modified by internal and external factors [...]
Valentyn Oksenych, Denis E. Kainov
doaj +6 more sources
DNA Damage Response Pathways in Dinoflagellates [PDF]
Microorganisms, 2019 Dinoflagellates are a general group of phytoplankton, ubiquitous in aquatic environments. Most dinoflagellates are non-obligate autotrophs, subjected to potential physical and chemical DNA-damaging agents, including UV irradiation, in the euphotic zone ...
Chongping Li, Joseph Tin Yum Wong
doaj +4 more sources
Lysine Crotonylation: An Emerging Player in DNA Damage Response
Biomolecules, 2022 The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated ...
Yuqin Zhao +8 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2010 Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity.
Giglia-Mari, G. +2 more
openaire +4 more sources
Cell Death and Disease, 2022 The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood.
Cha Kyung Youn +10 more
doaj +1 more source
Engineering a DNA damage response without DNA damage [PDF]
Genome Biology, 2008 Recent work has achieved the feat of activating the DNA damage checkpoint in the absence of DNA damage, revealing the importance of protein-chromatin associations for the activation, amplification and maintenance of the DNA damage response.
Yeung, ManTek, Durocher, Daniel
openaire +2 more sources
ULK1 in autophagy: sugar it up
Autophagy Reports, 2022 Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Sheng Yan, Jing Li
doaj +1 more source
PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP
Frontiers in Cell and Developmental Biology, 2022 Homologous recombination (HR) is an error-free DNA double-strand break (DSB) repair pathway, which safeguards genome integrity and cell viability. Human C-terminal binding protein (CtBP)—interacting protein (CtIP) is a central regulator of the pathway ...
Zhiyu Qiu +8 more
doaj +1 more source
Radiation-induced DNA damage responses [PDF]
Radiation Protection Dosimetry, 2006 The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage ...
Jeggo, Penny, Löbrich, Markus
openaire +2 more sources
DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target
Frontiers in Oncology, 2022 DNA lesions arising from both exogenous and endogenous sources occur frequently in DNA. During DNA replication, the presence of unrepaired DNA damage in the template can arrest replication fork progression, leading to fork collapse, double-strand break ...
Ashlynn Ai Li Ler +2 more
doaj +1 more source