Results 1 to 10 of about 1,846,477 (392)

Interplay of space radiation and microgravity in DNA damage and DNA damage response [PDF]

npj Microgravity, 2017
In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms.
María Moreno-Villanueva, Michael Wong, Tao Lu, Ye Zhang, Honglu Wu   +4 more
doaj   +4 more sources

DNA Damage Response and Immune Defense [PDF]

International Journal of Molecular Sciences, 2020
DNA damage is the cause of numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn, coordinates DNA damage checkpoint activation and promotes the removal of DNA lesions. In
Claudia Nastasi, Laura Mannarino, Maurizio D’Incalci   +2 more
openalex   +2 more sources

The Mitochondrial Response to DNA Damage

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are double membrane organelles in eukaryotic cells that provide energy by generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are crucial to many aspects of cellular metabolism.
Ziye Rong, Peipei Tu, Peiqi Xu, Yan Sun, Fangfang Yu, Na Tu, Lixia Guo, Yanan Yang   +7 more
doaj   +2 more sources

Imaging the time course of DNA damage response at a nonrepetitive endogenous locus. [PDF]

Cell Rep Methods
Rybczynski AT, Cottle WT, Chen PT, Kwon J, Shang T, Wang Y, Meneses P, Pangeni S, Park Y, Gavrilov M, Ha T.   +10 more
europepmc   +2 more sources

State-of-the-art strategies for targeting the DNA damage response in cancer

Nature Reviews Clinical Oncology, 2018
Chad Tang, Gordon B Mills, Timothy A Yap
exaly   +2 more sources

Lysine Crotonylation: An Emerging Player in DNA Damage Response

Biomolecules, 2022
The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated ...
Yuqin Zhao, Shuailin Hao, Wenchi Wu, Youhang Li, Kaiping Hou, Yu Liu, Wei Cui, Xingzhi Xu, Hailong Wang   +8 more
doaj   +1 more source

HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells

Cell Death and Disease, 2022
The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood.
Cha Kyung Youn, Jung-Hee Lee, Gurusamy Hariharasudhan, Hong Beum Kim, Jeeho Kim, Sumi Lee, Sung-Chul Lim, Sang-Pil Yoon, Sang-Gon Park, In-Youb Chang, Ho Jin You   +10 more
doaj   +1 more source

ULK1 in autophagy: sugar it up

Autophagy Reports, 2022
Autophagy is a highly conserved cellular degradation and recycling process in mammalian cells, which is comprised of three main types: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA).
Sheng Yan, Jing Li
doaj   +1 more source

PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP

Frontiers in Cell and Developmental Biology, 2022
Homologous recombination (HR) is an error-free DNA double-strand break (DSB) repair pathway, which safeguards genome integrity and cell viability. Human C-terminal binding protein (CtBP)—interacting protein (CtIP) is a central regulator of the pathway ...
Zhiyu Qiu, Shuailin Hao, Shikai Song, Ruiling Zhang, Tingyu Yan, Zhifang Lu, Hailong Wang, Zongchao Jia, Jimin Zheng   +8 more
doaj   +1 more source

DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]

, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W, Cohen, Shirli, Gomez Godinez, Veronica, Kabbara, Sami, Kong, Xiangduo, Maravillas-Montero, Jose Luis, Preece, Daryl, Sherman, Adria, Shi, Zhixia, Wu, Tao, Yokomori, Kyoko   +10 more
core   +1 more source