Results 1 to 10 of about 1,287,961 (310)

The interplay between DNA damage response and mitochondrial dysfunction in radiotherapy. [PDF]

Front Oncol
Yang S, Li Y, Zhang J, Shen A, Hu B, Yan J.   +5 more
europepmc   +2 more sources

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

Science, 2015
Chanhee Kang, Qikai Xu, Timothy D. Martin, Mamie Z. Li, Marco Demaria, Liviu Aron, Tao Lu, Bruce A. Yankner, Judith Campisi, Stephen J. Elledge   +9 more
openalex   +2 more sources

State-of-the-art strategies for targeting the DNA damage response in cancer

Nature Reviews Clinical Oncology, 2018
Chad Tang, Gordon B Mills, Timothy A Yap
exaly   +2 more sources

Corrigendum to Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis. [PDF]

J Clin Invest
Su D, Ma S, Shan L, Wang Y, Wang Y, Cao C, Liu B, Yang C, Wang L, Tian S, Ding X, Liu X, Yu N, Song N, Liu L, Yang S, Zhang Q, Yang F, Zhang K, Shi L.   +19 more
europepmc   +3 more sources

Chromatin compartmentalization regulates the response to DNA damage

Nature, 2023
The DNA damage response is essential to safeguard genome integrity. Although the contribution of chromatin in DNA repair has been investigated^ 1 , 2 , the contribution of chromosome folding to these processes remains unclear^ 3 .
C. Arnould, V. Rocher, Florian Saur, Aldo S. Bader, F. Muzzopappa, Sarah Collins, E. Lesage, Benjamin Le Bozec, Nadine Puget, T. Clouaire, T. Mangeat, Raphaël Mourad, N. Ahituv, D. Noordermeer, Fabian Erdel, Martin Bushell, A. Marnef, G. Legube   +17 more
semanticscholar   +1 more source

DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities

Experimental and Molecular Medicine, 2022
Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy.
Yasser Abuetabh, H. H. Wu, Chengsen Chai, Habib Al Yousef, S. Persad, C. Sergi, Roger P Leng   +6 more
semanticscholar   +1 more source

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

Signal Transduction and Targeted Therapy, 2020
Radiotherapy is one of the most common countermeasures for treating a wide range of tumors. However, the radioresistance of cancer cells is still a major limitation for radiotherapy applications.
Rui-Xue Huang, P. Zhou
semanticscholar   +1 more source

DNA-PKcs: A Multi-Faceted Player in DNA Damage Response

Frontiers in Genetics, 2020
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a member of the phosphatidylinositol 3-kinase related kinase family, which can phosphorylate more than 700 substrates.
Xiaoqiao Yue, Chenjun Bai, Dafei Xie, Teng Ma, P. Zhou   +4 more
semanticscholar   +1 more source

Long noncoding RNA SNHG12 integrates a DNA-PK–mediated DNA damage response and vascular senescence

Science Translational Medicine, 2020
Deficiency of lncRNA SNHG12 impairs DNA damage repair in the vessel wall and predisposes to vascular senescence and atherosclerosis. A senescent lnc to atherosclerosis DNA damage and senescence are thought to enhance atherosclerotic lesion formation ...
S. Haemmig, Dafeng Yang, Xinghui Sun, Debapria Das, S. Ghaffari, R. Molinaro, Lei Chen, Yihuan Deng, D. Freeman, N. Moullan, Yevgenia Tesmenitsky, A. Wara, Viorel Simion, E. Shvartz, James F. Lee, Tianlun Yang, Galina Sukova, J. Marto, P. Stone, Warren L. Lee, J. Auwerx, P. Libby, M. W. Feinberg   +22 more
semanticscholar   +1 more source

DNA Damage Response and Immune Defense

International Journal of Molecular Sciences, 2020
DNA damage is the cause of numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn, coordinates DNA damage checkpoint activation and promotes the removal of DNA lesions. In
C. Nastasi, L. Mannarino, M. D’Incalci
semanticscholar   +1 more source