Results 21 to 30 of about 1,287,961 (310)
Cell Reports, 2014 The R2TP cochaperone complex plays a critical role in the assembly of multisubunit machines, including small nucleolar ribonucleoproteins (snoRNPs), RNA polymerase II, and the mTORC1 and SMG1 kinase complexes, but the molecular basis of substrate ...
Zuzana Hořejší +9 more
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Medulloblastoma and the DNA Damage Response
Frontiers in Oncology, 2022 Medulloblastoma (MB) is the most common malignant brain tumor in children with standard of care consisting of surgery, radiation, and chemotherapy. Recent molecular profiling led to the identification of four molecularly distinct MB subgroups – Wingless (
Leon F. McSwain +9 more
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Autophagic Organelles in DNA Damage Response
Frontiers in Cell and Developmental Biology, 2021 Autophagy is an important subcellular event engaged in the maintenance of cellular homeostasis via the degradation of cargo proteins and malfunctioning organelles.
Jeongha Kim +7 more
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CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
Nature Network Boston, 2018 Here, we report that genome editing by CRISPR–Cas9 induces a p53-mediated DNA damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, leading to a selection against cells with a functional p53 pathway.
E. Haapaniemi +4 more
semanticscholar +1 more source
Bacterial Genotoxin-Induced DNA Damage and Modulation of the Host Immune Microenvironment
Toxins, 2020 Bacterial genotoxins (BTGX) induce DNA damage, which results in senescence or apoptosis of the target cells if not properly repaired. Three BTGXs have been identified: the cytolethal distending toxin (CDT) family produced by several Gram-negative ...
Océane C.B. Martin, Teresa Frisan
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The concerted roles of FANCM and Rad52 in the protection of common fragile sites
Nature Communications, 2018 Fanconi anemia core proteins have been linked to common fragile site stability. Here the authors shed light into the role of FANCM in common fragile site protection by suppressing double-strand break formation and mitotic recombination.
Hailong Wang +5 more
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RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility
Cell Reports, 2014 Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure.
Aisling Frizzell +6 more
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Exploring the links between cancer and placenta development [PDF]
Open Biology, 2018 The development of metastatic cancer is a multistage process, which often requires decades to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors generate genetically heterogeneous cell populations.
Vincenzo Costanzo +3 more
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The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer
International Journal of Molecular Sciences, 2019 Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy, senescence, proliferation, aging, and tumorigenesis.
D. Alves-Fernandes, M. Jasiulionis
semanticscholar +1 more source
Histone post-translational modification and the DNA damage response
Genes and Diseases, 2023 DNA is highly vulnerable to spontaneous and environmental timely damage in living cells. DNA damage may cause genetic instability and increase cancer risk if the damages are not repaired timely and efficiently.
Haoyun Song +6 more
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