Results 11 to 20 of about 2,054,868 (263)

Structural and Dynamic Features of the Recognition of 8-oxoguanosine Paired with an 8-oxoG-clamp by Human 8-oxoguanine-DNA Glycosylase [PDF]

Current Issues in Molecular Biology
8-oxoguanine (oxoG) is formed in DNA by the action of reactive oxygen species. As a highly mutagenic and the most common oxidative DNA lesion, it is an important marker of oxidative stress. Human 8-oxoguanine-DNA glycosylase (OGG1) is responsible for its
Maria V. Lukina, Polina V. Zhdanova, Vladimir V. Koval   +2 more
doaj   +2 more sources

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA [PDF]

Nature Chemical Biology, 2012
Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a key oxidation product of 5-methylcytosine in a recently discovered cytosine demethylation pathway.
Liang Zhang, Xingyu Lu, Junyan Lu, Haihua Liang, Qing Dai, Guo-Liang Xu, Cheng Luo, Hualiang Jiang, Chuan He   +8 more
semanticscholar   +3 more sources

DEMETER DNA Glycosylase Establishes MEDEA Polycomb Gene Self-Imprinting by Allele-Specific Demethylation [PDF]

Cell, 2006
Mary Gehring, Jin Hoe Huh, Tzung‐Fu Hsieh, Jon Penterman, Yeonhee Choi, John J. Harada, Robert B. Goldberg, Robert L. Fischer   +7 more
openalex   +2 more sources

Crystal structure of MutYX: a novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-oxoguanine recognition sphere. [PDF]

Nucleic Acids Res
Trasviña-Arenas CH, Hashemian M, Malek M, Merrill S, Fisher AJ, David SS.   +5 more
europepmc   +2 more sources

The compost metagenome as a source of T4 bacteriophage pyrimidine dimer glycosylase homologues [PDF]

E3S Web of Conferences, 2021
Compost is a promising source of thermotolerant enzymes for their application in biotechnology. Homologues of bacteriophage T4 DNA glycosylase can find their application in pharmaceuticals and perfumery.
Karmanova Alexandra N., Lu Yinhua, Zimin Andrei A.   +2 more
doaj   +1 more source

Anchored linear oligonucleotides: the effective tool for the real-time measurement of uracil DNA glycosylase activity

Open Biology, 2021
Base excision repair is one of the important DNA repair mechanisms in cells. The fundamental role in this complex process is played by DNA glycosylases.
Anna Ligasová, Ivan Rosenberg, Markéta Bocková, Jiří Homola, Karel Koberna   +4 more
doaj   +1 more source

Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening

Biochemistry and Biophysics Reports, 2021
Uracil DNA glycosylases are an important class of enzymes that hydrolyze the N-glycosidic bond between the uracil base and the deoxyribose sugar to initiate uracil excision repair.
Avani Mehta, Prateek Raj, Sandeep Sundriyal, Balasubramanian Gopal, Umesh Varshney   +4 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells

Journal of Biological Chemistry, 2020
Infection with the Gram-negative, microaerophilic bacterium Helicobacter pylori induces an inflammatory response and oxidative DNA damage in gastric epithelial cells that can lead to gastric cancer (GC).
I. Sayed, A. Şahan, T. Venkova, Anirban Chakraborty, Dibyabrata Mukhopadhyay, D. Bimczok, E. Beswick, V. Reyes, I. Pinchuk, D. Sahoo, P. Ghosh, T. Hazra, Soumita Das   +12 more
semanticscholar   +1 more source

Inhibition of DNA glycosylases via small molecule purine analogs. [PDF]

PLoS ONE, 2013
Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed.
Aaron C Jacobs, Marcus J Calkins, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Miral Dizdaroglu, Amanda K McCullough, R Stephen Lloyd   +9 more
doaj   +1 more source