A thermophilic 8-oxoguanine DNA glycosylase from Thermococcus barophiluss Ch5 is a new member of AGOG DNA glycosylase family [PDF]
Acta Biochimica et Biophysica Sinica, 2022 8-Oxoguanine (8oxoG) in DNA is a major oxidized base that poses a severe threat to genome stability. To counteract the mutagenic effect generated by 8oxoG in DNA, cells have evolved 8oxoG DNA glycosylase (OGG) that can excise this oxidized base from DNA.
Wang Lei, Jiang Donghao, Zhang Likui
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Mismatch uracil DNA glycosylase (Mug) is maintained in the Corynebacterium pseudotuberculosis genome and exhibits affinity for uracil but not other types of damage [PDF]
Genetics and Molecular BiologyThe genome of Corynebacterium pseudotuberculosis, etiologic agent of Caseous Lymphadenitis (CLA), was sequenced to comprehend its genetics, pathogenicity, and virulence mechanisms due to its economic importance.
Bruno Carvalho Resende +9 more
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Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome [PDF]
Cell Discovery, 2023 The engagement of a DNA glycosylase with a damaged DNA base marks the initiation of base excision repair. Nucleosome-based packaging of eukaryotic genome obstructs DNA accessibility, and how DNA glycosylases locate the substrate site on nucleosomes is ...
Lvqin Zheng, Bin Tsai, Ning Gao
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Targeted deaminase-free T-to-G and C-to-K base editing in rice by fused human uracil DNA glycosylase variants. [PDF]
Plant Biotechnol JPlant Biotechnology Journal, Volume 23, Issue 4, Page 1257-1259, April 2025.
Wu Y +7 more
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Structural and Dynamic Features of the Recognition of 8-oxoguanosine Paired with an 8-oxoG-clamp by Human 8-oxoguanine-DNA Glycosylase [PDF]
Current Issues in Molecular Biology8-oxoguanine (oxoG) is formed in DNA by the action of reactive oxygen species. As a highly mutagenic and the most common oxidative DNA lesion, it is an important marker of oxidative stress. Human 8-oxoguanine-DNA glycosylase (OGG1) is responsible for its
Maria V. Lukina +2 more
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Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase [PDF]
Nature CommunicationsDNA base editing technologies predominantly utilize engineered deaminases, limiting their ability to edit thymine and guanine directly. In this study, we successfully achieve base editing of both cytidine and thymine by leveraging the translesion DNA ...
Zongyi Yi +10 more
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The compost metagenome as a source of T4 bacteriophage pyrimidine dimer glycosylase homologues [PDF]
E3S Web of Conferences, 2021 Compost is a promising source of thermotolerant enzymes for their application in biotechnology. Homologues of bacteriophage T4 DNA glycosylase can find their application in pharmaceuticals and perfumery.
Karmanova Alexandra N. +2 more
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Open Biology, 2021 Base excision repair is one of the important DNA repair mechanisms in cells. The fundamental role in this complex process is played by DNA glycosylases.
Anna Ligasová +4 more
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Inhibition of DNA glycosylases via small molecule purine analogs. [PDF]
PLoS ONE, 2013 Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed.
Aaron C Jacobs +9 more
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Acta Biochimica et Biophysica Sinica, 2022 DNA glycosylase, as one member of DNA repair machineries, plays an essential role in correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond between the sugar and target nucleobase through the base excision repair (BER) pathways ...
Wang Lingyan +3 more
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