Results 91 to 100 of about 2,102,008 (248)

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for detection of Leishmania DNA in buffy coat from visceral leishmaniasis patients [PDF]

, 2012
BACKGROUND: Visceral leishmaniasis (VL) remains as one of the most neglected tropical diseases with over 60% of the world's total VL cases occurring in the Indian subcontinent.
Mondal, D., Khondaker Rifat Hasan Bhaskar, Tania Akther, Gerd Pluschke, Bhaskar, Khondaker Rifat Hasan, Pluschke Gerd, Akther, Tania, Salam, M. A., Mondal, Dinesh, Khan, M. G., Khan Md Gulam Musawwir, Salam Md Abdus, Akther Tania, Dinesh Mondal, Pluschke, G., Md Abdus Salam, Khan, Md. Gulam Musawwir, Salam, Md. Abdus, Mondal Dinesh, Bhaskar Khondaker Rifat Hasan, Md Gulam Musawwir Khan, Akther, T., Pluschke, Gerd, Bhaskar, K. R.   +23 more
core   +1 more source

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

RNAP II antagonizes mitotic chromatin folding and chromosome segregation by condensin

Cell Reports
Summary: Condensin shapes mitotic chromosomes by folding chromatin into loops, but whether it does so by DNA-loop extrusion remains speculative. Although loop-extruding cohesin is stalled by transcription, the impact of transcription on condensin, which ...
Jérémy Lebreton, Léonard Colin, Elodie Chatre, Pascal Bernard   +3 more
doaj   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Loop Extrusion Machinery Impairments in Models and Disease

Cells
Structural maintenance of chromosomes (SMC) complexes play a crucial role in organizing the three-dimensional structure of chromatin, facilitating key processes such as gene regulation, DNA repair, and chromosome segregation.
Anastasiya Ryzhkova, Ekaterina Maltseva, Nariman Battulin, Evelyn Kabirova   +3 more
doaj   +1 more source

The role of cohesin and DNA loop extrusion in the generation of single neuron identity

Current Opinion in Genetics & Development
Stochastic and combinatorial expression of clustered Protocadherin (Pcdh) genes generates extraordinary cell-surface protein diversity, which provides individual neurons with a unique cell surface 'barcode' that functions in neuronal self/non-self discrimination.
Lea Kiefer, Tom Maniatis, Daniele Canzio
openaire   +2 more sources

Male reproductive system in stenopodidean shrimps: Unveiling basal reproductive traits in shrimp‐like Pleocyemata (Stenopodidae and Spongicolidae)

The Anatomical Record, EarlyView.
Abstract Stenopodidea represents one of the basal lineages within Pleocyemata, yet the male reproductive system (MRS) of this group remains poorly understood, with limited information available regarding its morphology and function. This study provides the first detailed description of the MRS in four stenopodidean shrimp species from two families ...
Caio Santos Nogueira, Lucas Rezende Penido Paschoal, Fernando José Zara   +2 more
wiley   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Markovian Dynamics in Chromatin Loop Extrusion Factors [PDF]

, 2020
Markov properties can be used to model different dynamic processes at various stages of the loop extrusion process. The current methods are proposed to gain insight on how Markov models may illustrate chromatin behaviour once the appropriate observed ...
Eng, Kathleen
core