Results 71 to 80 of about 2,219,993 (156)

The role of cohesin and DNA loop extrusion in the generation of single neuron identity

Current Opinion in Genetics & Development
Stochastic and combinatorial expression of clustered Protocadherin (Pcdh) genes generates extraordinary cell-surface protein diversity, which provides individual neurons with a unique cell surface 'barcode' that functions in neuronal self/non-self discrimination.
Lea Kiefer, Tom Maniatis, Daniele Canzio
openaire   +2 more sources

Loop Extrusion Machinery Impairments in Models and Disease

Cells
Structural maintenance of chromosomes (SMC) complexes play a crucial role in organizing the three-dimensional structure of chromatin, facilitating key processes such as gene regulation, DNA repair, and chromosome segregation.
Anastasiya Ryzhkova, Ekaterina Maltseva, Nariman Battulin, Evelyn Kabirova   +3 more
doaj   +1 more source

Regulation of pericentromeric DNA loop size via Scc2-cohesin interaction

iScience
Summary: Cohesin exhibits DNA loop extrusion when bound to the ATPase activator Scc2 (NIPBL in humans), which has been proposed to organize higher-order chromosome folding. In budding yeast, most chromosome-bound cohesins lack Scc2.
Sao Anh Nguyen, Toyonori Sakata, Katsuhiko Shirahige, Takashi Sutani   +3 more
doaj   +1 more source

Mechanism of DNA Entrapment by a Loop-Extruding Wadjet SMC Motor

Structural Maintenance of Chromosome (SMC) complexes perform critical functions by folding DNA through loop extrusion. Choreography and outcome of SMC DNA loading prior to loop extrusion, however, remain elusive.
ROISNE-HAMELIN, Florian
core   +2 more sources

Emerging Evidence of Chromosome Folding by Loop Extrusion

, 2018
Chromosome organization poses a remarkable physical problem with many biological consequences: how can molecular interactions between proteins at the nanometer scale organize micron-long chromatinized DNA molecules, insulating or facilitating ...
Leonid A. Mirny, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Anton Goloborodko   +4 more
core   +1 more source

Functional interplay between condensin I and topoisomerase IIα in single-molecule DNA compaction

Nature Communications
Condensin I and topoisomerase IIα (topo IIα) are chromosomal ATPases essential for mitotic chromosome assembly. Mechanistically how the two ATPases cooperate to assemble mitotic chromosomes remains unknown.
Yuko Tsubota, Keishi Shintomi, Kazuhisa Kinoshita, Yuki Masahara-Negishi, Yuuki Aizawa, Masami Shima, Tatsuya Hirano, Tomoko Nishiyama   +7 more
doaj   +1 more source

RNA polymerases as moving barriers to condensin loop extrusion

, 2019
To separate replicated sister chromatids during mitosis, eukaryotes and prokaryotes have structural maintenance of chromosome (SMC) condensin complexes that were recently shown to organize chromosomes by a process known as DNA loop extrusion.
Paul, Payel, Wang, Xindan, van den Berg, Aafke A, Brandao, Hugo B., Rudner, David Z., Mirny, Leonid A   +5 more
core   +1 more source

Cohesin positions the epigenetic reader Phf2 within the genome

The EMBO Journal
Genomic DNA is assembled into chromatin by histones, and extruded into loops by cohesin. These mechanisms control important genomic functions, but whether histones and cohesin cooperate in genome regulation is poorly understood.
Wen Tang, Lorenzo Costantino, Roman Stocsits, Gordana Wutz, Rene Ladurner, Otto Hudecz, Karl Mechtler, Jan-Michael Peters   +7 more
doaj   +1 more source

Emerging Evidence of Chromosome Folding by Loop Extrusion

, 2017
Chromosome organization poses a remarkable physical problem with many biological consequences: How can molecular interactions between proteins at the nanometer scale organize micron-long chromatinized DNA molecules, insulating or facilitating ...
Imakaev, Maxim, Fudenberg, Geoffrey, Goloborodko, Anton, Abdennur, Nezar Alexander, Mirny, Leonid A., Leonid A. Mirny, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Anton Goloborodko   +9 more
core   +1 more source

Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast.

, 2021
Underlying higher order chromatin organization are Structural Maintenance of Chromosomes (SMC) complexes, large protein rings that entrap DNA. The molecular mechanism by which SMC complexes organize chromatin is as yet incompletely understood.
Yasutaka Kakui (8961683), Tereza Gerguri (5728253), Christopher Barrington (9608422), Frank Uhlmann (54006), Xiao Fu (74654), Paul A Bates (8155419), Bhavin S Khatri (8274705)   +6 more
core