Results 121 to 130 of about 9,982 (202)

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury

The Journal of Physiology, EarlyView.
Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich, Ulas Ozkurede, Shanmugasundaram Pakkiriswami, Ryan Gemilere, Samira M. Azarin, Julia C. Liu   +5 more
wiley   +1 more source

Phenotypic expression of the gene‐for‐gene interaction in plant pathogenic bacteria: An implication for resistance to bacterial diseases by plants

Agrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Plant pathogenic bacteria cause massive losses in agriculture and damage to natural plant habitats. Bacterial pathogens not only reduce crop production, but they also reduce crop quality by releasing toxins into the environment. Pathogenic bacteria that invade plant tissues must overcome the plant's defense mechanisms. Plants possess an innate
Muluken Getahun, Zelalem Bekeko
wiley   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

All eukaryotic SMC proteins induce a twist of -0.6 at each DNA loop extrusion step. [PDF]

Sci Adv
Janissen R, Barth R, Davidson IF, Peters JM, Dekker C.   +4 more
europepmc   +1 more source

Sustainable Polymer Biocomposites for Food Packaging: Green Nanotechnology, Circular Plastic Upcycling and Smart Functional Materials

Packaging Technology and Science, Volume 39, Issue 9, Page 1141-1178, September 2026.
Graphical abstract showing the development of biodegradable polymer biocomposites reinforced with natural fibres, green nanoparticles and waste‐plastic upcycling pathways toward sustainable smart food packaging materials ABSTRACT The fundamental hypothesis behind this review is that the combination of biodegradable polymer‐based biocomposites, which ...
Chandra Sekhar Espenti, Jaewoong Lee
wiley   +1 more source

Molecular dynamics simulations of human cohesin subunits identify DNA binding sites and their potential roles in DNA loop extrusion. [PDF]

PLoS Comput Biol
Gu C, Takada S, Brandani GB, Terakawa T.
europepmc   +1 more source

Development of plant‐derived biomimetic nanoparticles as a novel targeted drug delivery platform

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Plant‐derived biomimetic nanoparticles (PD‐BNPs) represent a sustainable and biocompatible nanoplatform for targeted drug delivery. This review highlights their therapeutic potential, engineering strategies, and translational challenges toward precision nanomedicine applications. Abstract Plant‐derived biomimetic nanoparticles (PD‐BNPs) have emerged as
Jihad Hasan, Asnaf Nihan Shuvo, Md. Rezaul Karim Sheikh, A. Nayeem Faruqui   +3 more
wiley   +1 more source

Can pseudotopological models for SMC-driven DNA loop extrusion explain the traversal of physical roadblocks bigger than the SMC ring size?

, 2022
Pradhan B, Barth R, Kim E, Davidson IF, van der Torre J, Peters J, Dekker C.   +6 more
europepmc   +1 more source

Applications of Bioinorganic Nano‐Based Delivery Systems—Diagnostics and Therapeutics

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Nanotechnology has emerged as a promising avenue for producing nanomedicines as alternatives to conventional drugs. Many organic nanoparticles, such as liposomes used in formulations like Doxil, Onivyde, and Marqibo, are approved by the Food and Drug Administration (FDA) and instrumental in treating various types of cancers.
Frank Ssengooba, Jubilee Andrew, Donald Fernandes   +2 more
wiley   +1 more source