Results 121 to 130 of about 2,219,993 (156)

Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation. [PDF]

Nat Commun
Stolper RJ, Tsang FH, Georgiades E, Hanssen LLP, Tunnacliffe EAJ, Downes DJ, Harrold CL, Hughes JR, Beagrie RA, Davies B, Kassouf MT, Higgs DR.   +11 more
europepmc   +1 more source

Loop extrusion dynamics and cooperative activation independently regulate enhancer-driven transcription

Friman ET, Juellig HJ, Alston G, Gomez-Acuna L, Boyle S, Flankova M, Munoz Grande A, Weykopf G, Mann A, Williamson I, Lettice LA, Bickmore WA.   +11 more
europepmc   +1 more source

CTCF Is a DNA-Tension-Dependent Barrier to Cohesin-Mediated Loop Extrusion

Nature, 2023
In eukaryotes, genomic DNA is extruded into loops by cohesin1. By restraining this process, the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating domains (TADs)2,3 that have important roles in gene regulation and ...
Cees Dekker, Roman Barth, Richard Janissen   +2 more
exaly   +6 more sources

Loop-Extrusion-Mediated Plasmid DNA Cleavage by the Bacterial SMC Wadjet Complex [PDF]

Molecular Cell
Structural maintenance of chromosomes (SMC) complexes play pivotal roles in genome organization and maintenance across all domains of life. In prokaryotes, SMC-family Wadjet complexes structurally resemble the widespread MukBEF but serve a defensive role
Kevin D Corbett, Eugene Kim, Biswajit Pradhan   +2 more
exaly   +6 more sources

Loop Extrusion as a Mechanism for Formation of DNA Damage Repair Foci

Nature, 2021
The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX (γH2AX), which act as seeds for the formation of DNA-damage response foci1. It is unclear how these
Raphaël Mourad, James E. Haber, Gaëlle Legube   +2 more
exaly   +8 more sources

DNA Loop Extrusion by Human Cohesin

Science, 2019
Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al.
Gordana Wutz, Jan-Michael Peters, Iain Finley Davidson   +2 more
exaly   +3 more sources