Results 131 to 140 of about 2,102,008 (248)

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Loop extrusion provides mechanical robustness to chromatin

Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop extrusion and investigate its mechanical consequences ...
Salari, Hossein, Jost, Daniel
core   +1 more source

Three‐Dimensional Optical and Computational Reconstruction of Colloidal Electrokinetic Flows via Multiplane Imaging and Multiscale Modeling

Small, EarlyView.
Fast 3D multiplane microscopy is combined with multiscale electrokinetic modeling to reconstruct nanoparticle motion around quadrupolar electrodes. This integrated optical‐computational framework reveals the full three‐dimensional structure of colloidal electrokinetic flows, including localized trapping, depletion layers, and complex vortical motion ...
Flip de Jong, Pablo Diez‐Silva, Jui‐Kai Chen, Raúl P. Peláez, Sudipta Seth, Bing‐Yang Shih, Senne Fransen, Radin Tahvildari, Kruti Trivedi, Rémi Pelletier, Harishankar Balakrishnan, Carmen Hervés‐Carrete, Carlos Renero‐Lecuna, Willem Van Roy, Maarten Rosmeulen, Santi Nonell, Susana Rocha, Andrey Klymchenko, Luis M. Liz‐Marzán, Roger Bresolí‐Obach, Manuel I. Marqués, Johan Hofkens, Rafael Delgado Buscalioni, Boris Louis   +23 more
wiley   +1 more source

Loop-mediated isothermal amplification (LAMP) test for detection of Trypanosoma evansi strain B [PDF]

, 2010
Camel Trypanosomiasis (Surra) is mainly caused by Trypanosoma evansi strains that express variable surface glycoprotein (VSG) RoTat 1.2 However, in Kenya a second causative strain that does not express RoTat 1.2 VSG (T. evansi type B) has been identified.
Njiru, Z.K., Enyaru, J.C., Dargantes, A.P., Ouma, J.O.   +3 more
core  

Hoberman‐Inspired Reconfigurable DNA Origami Ring for Nanoscale Capture

Small, EarlyView.
A Hoberman‐inspired DNA origami ring with coupled scissor‐like motion is designed and assembled. Reversible reconfiguration produces different conformations for organization of gold nanoparticles and capture of DNA nanostructures with varied sizes and geometries. ABSTRACT Dynamic DNA origami systems have enabled programmable nanoscale motion and target‐
Henry Wisniewski, Minu Saji, Moisés Reyes, Qi Yang, Fei Zhang   +4 more
wiley   +1 more source

Innovative 3D‐bioprinted microfibers in calcium phosphate cement platform with Nell‐1 to activate nerve‐bone axis for synergistic bone, vasculature, and nanofibrous nerve regeneration

Smart Molecules, EarlyView.
A 3D‐bioprinted platform with stem cells activates “nerve‐bone” signaling by enabling the spatiotemporal delivery of Nell‐1. This activation enhances neurovascular and bone regeneration through the CYFIP1 cascade. In rat calvarial defects, the platform doubled bone regeneration and nerve repair and tripled vascular density, resulting in superior ...
Minjia Zhu, Xinyi Li, Jingyi Li, Kan Yu, Zixiang Dai, Le Xiao, Qinrou Zhang, Zihan Jia, Qingchen Qiao, Zeqing Zhao, Ke Zhang, Yuxing Bai   +11 more
wiley   +1 more source

Replisomes restrict SMC translocation in vivo

Nature Communications
Structural maintenance of chromosomes (SMC) complexes organize genomes by extruding DNA loops, while replisomes duplicate entire chromosomes. These essential molecular machines must collide frequently in every cell cycle, yet how such collisions are ...
Qin Liao, Hugo B. Brandão, Zhongqing Ren, Xindan Wang   +3 more
doaj   +1 more source

Turning the Mre11/Rad50 DNA repair complex on its head: lessons from SMC protein hinges, dynamic coiled-coil movements and DNA loop-extrusion? [PDF]

Biochem Soc Trans, 2020
Zabolotnaya E, Mela I, Henderson RM, Robinson NP.   +3 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

An upstream secondary DNA motif within the IL3 insulator CTCF binding site is required for enhancer-blocking insulator activity.

PLoS ONE
CCCTC-binding Factor (CTCF) is the only known vertebrate protein that functions to organise the genome into distinct functional chromatin domains. A subset of CTCF sites also provide insulator activity and barrier activity to block inappropriate enhancer-
Sarion R Bowers, Peter N Cockerill
doaj   +1 more source