Results 211 to 220 of about 70,351 (245)
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DNA mismatch repair and cancer
Gastroenterology, 1995The genetic basis of cancer involves certain classes of genes, particularly oncogenes, tumor-suppressor genes, and DNA mismatch repair genes. Originally identified in bacteria and yeast, the human homologues of DNA mismatch repair genes have been implicated in the pathogenesis of the hereditary nonpolyposis colorectal cancer syndromes, as well as a ...
D C, Chung, A K, Rustgi
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Pharmacology & Therapeutics, 2018
Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent polymorphism in short repetitive DNA sequences and single nucleotide substitution, as consequence of DNA mismatch repair (MMR) deficiency. MSI secondary to germline mutation in DNA MMR proteins is the molecular fingerprint of Lynch syndrome (LS), while ...
Marina, Baretti, Dung T, Le
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Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent polymorphism in short repetitive DNA sequences and single nucleotide substitution, as consequence of DNA mismatch repair (MMR) deficiency. MSI secondary to germline mutation in DNA MMR proteins is the molecular fingerprint of Lynch syndrome (LS), while ...
Marina, Baretti, Dung T, Le
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Phosphorylation meets DNA mismatch repair
DNA Repair, 2018DNA mismatch repair (MMR) is a highly conserved process and ensures the removal of mispaired DNA bases and insertion-deletion loops right after replication. For this, a MutSα or MutSβ protein complex recognizes the DNA damage, MutLα nicks the erroneous strand, exonuclease 1 removes the wrong nucleotides, DNA polymerase δ refills the gap and DNA ligase ...
Isabel Madeleine Weßbecher +1 more
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DNA Mismatch Repair: Functions and Mechanisms
Chemical Reviews, 2005AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ravi R, Iyer +3 more
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1998
Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic tumours.
M. O’Driscoll, O. Humbert, P. Karran
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Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic tumours.
M. O’Driscoll, O. Humbert, P. Karran
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DNA mismatch repair and cancer
Frontiers in Bioscience, 2003DNA mismatch repair (MMR) is an important genome caretaker system. It ensures genomic stability by correcting mismatches generated during DNA replication and recombination and by triggering apoptosis of cells with large amounts of DNA damage. Protein components responsible for these reactions are highly conserved through evolution, and homologs of ...
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DNA mismatch repair and cancer
Mutation Research/Reviews in Mutation Research, 2001Five human DNA mismatch repair genes have been identified that, when mutated, cause susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC). Mutational inactivation of both copies of a DNA mismatch repair gene results in a profound repair defect and progressive accumulation of mutations throughout the genome.
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Targeting DNA mismatch repair for radiosensitization
Seminars in Radiation Oncology, 2001Postreplicational mismatch repair (MMR) proteins are capable of recognizing and processing not only single base-pair mismatches and insertion-deletion loops (IDLs) that occur during DNA replication, but also adducts in DNA resulting from treatment with cancer chemotherapy agents.
S E, Berry, T J, Kinsella
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Mismatch repair and DNA damage signalling
DNA Repair, 2004Postreplicative mismatch repair (MMR) increases the fidelity of DNA replication by up to three orders of magnitude, through correcting DNA polymerase errors that escaped proofreading. MMR also controls homologous recombination (HR) by aborting strand exchange between divergent DNA sequences. In recent years, MMR has also been implicated in the response
Stojic, L, Brun, R, Jiricny, J
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DNA Mismatch Repair and Colon Cancer
2006The Mismatch Repair (MMR) system is the major pathway responsible for repair of base-base mispairs and short insertion/deletion loops (IDLs) that arise during DNA replication and as intermediates of homologous recombination. Left unrepaired, these structures will give rise to basesubstitution and frameshift mutations, respectively.
Marra, Giancarlo, Jiricny, Josef
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