Results 91 to 100 of about 77,870 (288)

Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]

, 2015
Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Abramov, AY, Angelova, PR, Gandhi, S, Horrocks, MH, Klenerman, D, Shchepinov, MS   +5 more
core   +2 more sources

Photooxidation of 18‐Carbon Polyunsaturated Fatty Acids to Prepare Mono‐Hydroxylated Octadecanoids

Lipids, EarlyView.
We developed a fast and simple one‐step synthetic strategy to produce mono‐hydroxylated metabolites based on the photosensitized oxidation of 18‐carbon polyunsaturated fatty acids (PUFAs). This approach could likely be extended to other PUFAs, suggesting that photosensitized oxidation could be employed to rapidly prepare hydroperoxides from multiple ...
Johanna Revol‐Cavalier, Mats Hamberg, Craig E. Wheelock   +2 more
wiley   +1 more source

Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study. [PDF]

, 2014
Backgroundn-3 fatty acids inhibit neuronal excitability and reduce seizures in animal models. High-dose fish oil has been explored in two randomised trials in drug resistant epilepsy with negative results.
DeGiorgio, Christopher M, Gornbein, Jeffrey, Harper, Ronald, Meymandi, Sheba, Miller, Patrick R, Schrader, Lara, Soss, Jason   +6 more
core   +1 more source

Effects of Docosahexaenoic Acid on Neurotransmission

Biomolecules and Therapeutics, 2012
Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid (PUFA) in the brain and a structural component of neuronal membranes. Changes in DHA content of neuronal membranes lead to functional changes in the activity of receptors and other proteins which might be associated with synaptic function.
Tanaka, Kazuhiro, Farooqui, Akhlaq A., Siddiqi, Nikhat J., Alhomida, Abdullah S., Ong, Wei-Yi   +4 more
openaire   +3 more sources

Eicosapentaenoic and Docosahexaenoic Acid Levels in Mouse Tissues After Intake of Echium and Ahiflower Oils Rich in Stearidonic and α‐Linolenic Acids

Lipids, EarlyView.
Dietary supplementation with stearidonic acid–rich Echium and Ahiflower oils increases EPA levels across multiple mouse tissues, while DHA responses remain tissue‐specific and limited, supporting the strategic use of plant‐based omega‐3 sources for EPA‐focused interventions. ABSTRACT Omega‐3 fatty acids (n‐3 FA), particularly eicosapentaenoic acid (EPA)
Letícia V. Segre, Mariana S. Bisinotto, Inar A. Castro   +2 more
wiley   +1 more source

LONG-CHAIN POLYUNSATURATED FATTY ACIDS AND THEIR ROLE IN CHILDREN NOURISHMENT

Вопросы современной педиатрии, 2012
The article deals with the mechanisms of metabolism of linoleic and α-linoleic polyunsaturated fatty acids as precursors of long-chain polyunsaturated fatty acids — arachidonic (ω-6 family) and docosahexaenoic acid (ω-3 famyli).
T. E. Borovik, S. G. Gribakin, V. A. Skvortsova, N. N. Semenova, T. N. Stepanova, N. G. Zvonkova   +5 more
doaj   +1 more source

SWATH Differential Abundance Proteomics and Cellular Assays Show In Vitro Anticancer Activity of Arachidonic Acid- and Docosahexaenoic Acid-Based Monoacylglycerols in HT-29 Colorectal Cancer Cells [PDF]

, 2019
Colorectal cancer (CRC) is one of the most common and mortal types of cancer. There is increasing evidence that some polyunsaturated fatty acids (PUFAs) exercise specific inhibitory actions on cancer cells through different mechanisms, as a previous ...
Fabrikov, Dmitri, González Fernández, María José, Guil Guerrero, José Luis, Ortea, Ignacio, Ramos Bueno, Rebeca Pilar   +4 more
core   +1 more source

Higher Increases in Plasma n‐3 Polyunsaturated Fatty Acids Following Fish Oil Supplementation in Postmenopausal Females Compared With Age‐Matched Males

Lipids, EarlyView.
ABSTRACT The effects of fish oil supplementation on omega‐3 (n‐3) polyunsaturated fatty acids, particularly intermediates between eicosapentaenoic acid (EPA, 20:5n‐3) and docosahexaenoic acid (DHA, 22:6n‐3), that may provide valuable metabolic information, have not been fully characterized in older populations.
David C. R. Ku, Insaf Loukil, Annick Vachon, Mélanie Plourde, Adam H. Metherel   +4 more
wiley   +1 more source

The Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Brown Adipogenesis in Stem Cell Culture [PDF]

, 2019
Polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are major maternal dietary supplements due to their positive benefits on neurological tissue growth during the first 12 weeks of gestation ...
Dahlem, Darynne
core   +2 more sources

Fit with good fat? The role of n-3 polyunsaturated fatty acids on exercise performance [PDF]

, 2016
N-3 PUFA (n-3) polyunsaturated fatty acids (PUFA) are a family of fatty acids mainly found in oily fish and fish oil supplements. The effects of n-3 PUFA on health are mainly derived from its anti-inflammatory proprieties and its influence on immune ...
Da Boit, Mariasole, Gray, Stuart M., Hunter, Angus M.   +2 more
core   +3 more sources