Results 101 to 110 of about 1,082,320 (275)

Docosahexanoic Acid Attenuates Palmitate-Induced Apoptosis by Autophagy Upregulation via GPR120/mTOR Axis in Insulin-Secreting Cells [PDF]

Endocrinology and Metabolism
Background Polyunsaturated fatty acids (PUFAs) reportedly have protective effects on pancreatic β-cells; however, the underlying mechanisms are unknown.
Seok-Woo Hong, Jinmi Lee, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee   +6 more
doaj   +1 more source

Dietary Fatty Acids, Cardiovascular Disease, and Life Expectancy Among Adults With Adverse Mental Health‐Related Characteristics: A Cohort‐Based Target Trial Emulation Study

Med Research, EarlyView.
This study highlights the cardiovascular and longevity benefits of dietary n‐3 PUFAs in individuals with adverse mental health‐related characteristics, particularly ALA and EPA. The target trial emulation framework further provides evidence, revealing EPA and DHA are associated with a lower early‐onset CVD risk in loneliness, while ALA and EPA are ...
Li Chen, Feipeng Cui, Tianqi Tan, Qi Wu, Ying Zhao, Huimin Chen, Zhilei Shan, Yuhan Tang, Xiao Yu, Qianchun Deng   +9 more
wiley   +1 more source

Plasma Lipid Remodeling across Preclinical Burden, Disease Onset, and Early Motor Severity in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background and Objectives Huntington's disease (HD) evolves silently for years before motor onset, yet the systemic metabolic alterations accompanying cumulative exposure to mutant huntingtin and disease progression remain poorly understood.
Mohamed Bendimerad, Dominique Bonneau, Clarisse Scherer‐Gagou, Adriana Prundean, Karim Chikh, Oriane Vitalis, Audrey Olivier, Odile Blanchet, Judith Nzoughet‐Kouassi, Christophe Verny, Pascal Reynier, Juan Manuel Chao de la Barca   +11 more
wiley   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids[S]

Journal of Lipid Research, 2010
Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely accepted but the mechanism(s) by which these fatty acids act remains unclear.
Christophe Morisseau, Bora Inceoglu, Kara Schmelzer, Hsing-Ju Tsai, Steven L. Jinks, Christine M. Hegedus, Bruce D. Hammock   +6 more
doaj   +1 more source

The Effect of Natural Compounds on Cognitive Impairment Through BDNF/TrkB/CREB Pathway: A Review

Phytotherapy Research, EarlyView.
Natural compounds improve cognitive function by activating BDNF/TrkB/CREB signaling to reduce neuroinflammation, oxidative stress, apoptosis, and Aβ accumulation while promoting synaptogenesis. ABSTRACT Considering the global prevalence of Alzheimer's disease (AD) and the restrictions of current treatment procedures, natural compounds (such as curcumin,
Vahid Pourbarkhordar, Sohrab Rahmani, Hossein Hosseinzadeh, Soghra Mehri   +3 more
wiley   +1 more source

Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm1

Journal of Lipid Research, 1998
Previously we demonstrated high concentrations of desmosterol and docosahexaenoic acid (DHA, 22:6 n–
William E. Connor, Don S. Lin, D.P. Wolf, M. Alexander   +3 more
doaj   +1 more source

Decreased Levels of Erythrocyte Membrane Arachidonic and Docosahexaenoic Acids Are Associated With Retinopathy of Prematurity. [PDF]

Invest Ophthalmol Vis Sci, 2022
Gillespie TC, Kim ES, Grogan T, Tsui I, Chu A, Calkins KL.   +5 more
europepmc   +1 more source

Transcriptomics Unveil Dsx1 as a Critical Regulator in Sexual Dimorphism of Crustaceans

Integrative Zoology, EarlyView.
Sexually dimorphic traits are involved in reproductive competition and are shaped by sex‐biased gene expression. This study identifies Dsx1 as a key male‐biased gene in Morinoia aosen and demonstrates through RNA interference that its disruption feminizes male‐specific T3 leg structures.
Yan Tong, Wenpei Xin, Zeyu Liu, Yami Zheng, Mengyi Huang, Hongguang Liu, Decai Lu, Wei Peng, Zhonge Hou   +8 more
wiley   +1 more source

Development of Hydrophobically Modified Casein Derivative-Based Delivery System for Docosahexaenoic Acids by an Acid-Induced Gelation. [PDF]

Food Sci Anim Resour, 2023
Ha HK, Woo DB, Lee MR, Lee WJ.
europepmc   +1 more source