Results 121 to 130 of about 1,082,320 (275)

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

open access: yesThe FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah   +5 more
wiley   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

open access: yesThe FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki   +7 more
wiley   +1 more source

Impact of fatty acid status on immune function of children in low-income countries.

open access: yes, 2011
In vitro and animal studies point to numerous mechanisms by which fatty acids, especially long-chain polyunsaturated fatty acids (LCPUFA), can modulate the innate and adaptive arms of the immune system.
Liandré van der Merwe   +3 more
core   +1 more source

Process for producing triacyglycerols containing arachidonic and docosahexaenoic acids for use in infant formulations

open access: yes, 2009
A process for producing triacylglycerols containing arachidonic and docosahexaenoic acids is provided by which involves separately hydrolysing the arachidonic acid enriched triacylglycerols and fish oil containing docosahaenoic acid to produce a free ...
Lo, Seong Koon, Lai, Oi Ming
core   +1 more source

Eicosapentaenoic and docosahexaenoic acids attenuate hyperglycemia through the microbiome-gut-organs axis in db/db mice. [PDF]

open access: yesMicrobiome, 2021
Zhuang P   +18 more
europepmc   +1 more source

LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy

open access: yesJournal of Diabetes Investigation, EarlyView.
MaR1 activates LGR6‐AMPK signaling to restore metabolic flexibility in diabetic hearts. Glycolytic recovery replenishes intracellular lactate to rescue protective protein lysine lactylation, which reactivates PINK1/Parkin‐mediated mitophagy to eliminate damaged mitochondria.
Bin Feng   +8 more
wiley   +1 more source

Biobehavioural and cerebral hemodynamic effects of omega-3 polyunsaturated fatty acids in healthy individuals [PDF]

open access: yes
The omega-3 polyunsaturated fatty acids (n-3 PUFAs) are a unique class of fatty acids that cannot be manufactured by the body, and must be acquired via dietary sources.
Jackson, Philippa
core  

Integrative polygenic analysis of the protective effects of fatty acid metabolism on disease as modified by obesity

open access: yesFrontiers in Nutrition
Dysregulation of fatty acid metabolites can play a crucial role in the progression of complex diseases, such as cardiovascular disease, digestive diseases, and metabolic diseases.
Courtney Astore, Greg Gibson
doaj   +1 more source

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