Results 51 to 60 of about 41,199 (244)

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Docosahexanoic Acid Attenuates Palmitate-Induced Apoptosis by Autophagy Upregulation via GPR120/mTOR Axis in Insulin-Secreting Cells [PDF]

Endocrinology and Metabolism
Background Polyunsaturated fatty acids (PUFAs) reportedly have protective effects on pancreatic β-cells; however, the underlying mechanisms are unknown.
Seok-Woo Hong, Jinmi Lee, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee   +6 more
doaj   +1 more source

Macronutrient and micronutrient profiles of meat types: insights into human health and diet

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş, Serap Göncü, Fatma Hepsağ, Nazan Koluman, Yesim Ozogul   +4 more
wiley   +1 more source

Omega-3 Fatty Acid Supplementation and Incident Age-Related Macular Degeneration in a United States Veteran Population: A Retrospective Cohort Study

Journal of Clinical & Translational Ophthalmology
Background: Higher intake of omega-3 fatty acids from food sources is associated with a reduced risk of age-related macular degeneration (AMD), but there are no recommended parameters for omega-3 fatty acid supplementation.
Angela A. Cao, Anders D. Westanmo, Amy A. Gravely, Karen R. Armbrust   +3 more
doaj   +1 more source

Baseline plasma fatty acids profile and incident cardiovascular events in the SU.FOL.OM3 trial: the evidence revisited.

PLoS ONE, 2014
ObjectiveWe aimed to investigate the association between baseline plasma fatty acids profile and the risk of future major cardiovascular events in patients with a history of ischaemic heart disease or ischemic stroke.MethodsBaseline plasma fatty acids as
Léopold K Fezeu, François Laporte, Emmanuelle Kesse-Guyot, Valentina A Andreeva, Jacques Blacher, Serge Hercberg, Pilar Galan   +6 more
doaj   +1 more source

Evaluating the Influence of Flaxseed Oil Against Docosahexaenoic Acid on Cancer Antigen CA15-3, Biochemical and Histopathological Parameters of DMBA-Induced Mammary Tumors Female Albino Wistar Rats. [PDF]

Food Sci Nutr
Flaxseed oil and docosahexaenoic acid administered to female Wistar rats with DMBA‐induced breast cancer help increase the HDL cholesterol and significantly reduce the CA15‐3, AST, ALT, LDL, and creatinine levels of rats compared to the negative control group. They also exhibited a protective effect on organs from histopathological data.
Aza HN, Djikeng FT, Ufuan AA, Fotsing IS, Zingue S.   +4 more
europepmc   +2 more sources

Depth and season‐related variability in fatty acid composition and lipid nutritional quality indices of farmed Mytilus galloprovincialis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Lipid quality is one of the most important indicators of the nutritional value of farmed mussels. In open‐coastal environments, factors such as cultivation depth and seasonal changes affect lipid dynamics, but their combined effects on lipid quality remain unclear.
Meryem Yeşim Çelik, Bayram Köstekli, Gülşen Uzun Gören, Zeynep Hasançavuşoğlu, Mümin Metehan Kılıç, Alihan Bülbül, Beyza Dündar   +6 more
wiley   +1 more source

Improved production of docosahexaenoic acid in batch fermentation by newly-isolated strains of Schizochytrium sp. and Thraustochytriidae sp. through bioprocess optimization

Synthetic and Systems Biotechnology, 2018
Thraustochytrids, rich in docosahexaenoic acid (DHA, C22:6ω3), represent a potential source of dietary fatty acids. Yet, the effect of culture conditions on growth and fatty acid composition vary widely among different thraustochytrid strains.
Qiuzhen Wang, Huike Ye, Biswarup Sen, Yunxuan Xie, Yaodong He, Sunghoon Park, Guangyi Wang   +6 more
doaj   +1 more source

A More Comprehensive Approach to the Neuroprotective Potential of Long-Chain Polyunsaturated Fatty Acids in Preterm Infants Is Needed—Should We Consider Maternal Diet and the n-6:n-3 Fatty Acid Ratio?

Frontiers in Pediatrics, 2020
There is growing evidence that long-chain polyunsaturated fatty acids (LCPUFAs) are of importance for normal brain development. Adequate supply of LCPUFAs may be particularly important for preterm infants, because the third trimester is an important ...
Susanna Klevebro, Sandra E. Juul, Thomas R. Wood   +2 more
doaj   +1 more source

Photooxidation of 18‐Carbon Polyunsaturated Fatty Acids to Prepare Mono‐Hydroxylated Octadecanoids

Lipids, EarlyView.
We developed a fast and simple one‐step synthetic strategy to produce mono‐hydroxylated metabolites based on the photosensitized oxidation of 18‐carbon polyunsaturated fatty acids (PUFAs). This approach could likely be extended to other PUFAs, suggesting that photosensitized oxidation could be employed to rapidly prepare hydroperoxides from multiple ...
Johanna Revol‐Cavalier, Mats Hamberg, Craig E. Wheelock   +2 more
wiley   +1 more source