Results 1 to 10 of about 29,411 (161)

Structural basis of mitochondrial receptor binding and constriction by DRP1 [PDF]

Nature, 2018
Mitochondrial inheritance, genome maintenance and metabolic adaptation depend on organelle fission by dynamin-related protein 1 (DRP1) and its mitochondrial receptors. DRP1 receptors include the paralogues mitochondrial dynamics proteins of 49 and 51 kDa
Raghav Kalia, Ray Yu-Ruei Wang, David A Agard   +2 more
exaly   +3 more sources

Excessive ER-mitochondria coupling: A DRP1-driven mechanism underlying mitochondrial dysfunction and impaired autophagy in stress-induced depression-like behavior in mice [PDF]

Redox Biology
Background: Depression is a common psychiatric disorder characterized by heightened stress exposure and disruptions in neuronal signaling. Growing evidence suggests that mitochondrial dysfunction contributes to its pathophysiology.
Jia-Rui Zhang, Jia-Yan Zhang, Qing-Ya Sun, Chang Chen, Jing-Wei Yang, Nan Cheng, Zi-Wen Guo, Ruo-Nan Shuang, Wei Gu, Meng-Ying Zhai, Jin-Ao Duan, Wei-Wei Tao   +11 more
doaj   +2 more sources

Regulation of mitochondrial morphology and metabolism by Jak-STAT pathway

Journal of Animal Reproduction and Biotechnology, 2021
Jak-STAT pathway is required for embryogenesis, female gametogenesis, cytokine-mediated neuroprotection, diabetes, obesity, cancer, stem cell, and various tissues.
Kun Do Rhee
doaj   +1 more source

Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells

International Journal of Hyperthermia, 2022
Objective The incidence rate of heat stroke (HS) has increased, with high morbidity and mortality rates, in recent years. Previous studies have suggested that vascular endothelial cell injury is one of the main pathological features of HS.
Wei Huang, Liangfeng Mao, Weidang Xie, Sumin Cai, Qiaobing Huang, Yanan Liu, Zhongqing Chen   +6 more
doaj   +1 more source

SENP3 Aggravates Renal Tubular Epithelial Cell Apoptosis in Lipopolysaccharide-Induced Acute Kidney Injury via deSUMOylation of Drp1

Kidney Diseases, 2022
Background: Sepsis causes acute kidney injury (AKI) in critically ill patients, although the mechanisms underlying the pathophysiology are not fully understood. SUMO-specific proteases 3 (SENP3), a member of the deSUMOylating enzyme family, is known as a
Lirui Wang, Jiangtao Li, Chen Yu
doaj   +1 more source

Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients

Biomolecules, 2020
Mitochondria are highly dynamic organelles that constantly fuse, divide, and move, and their function is regulated and maintained by their morphologic changes. Mitochondrial disease (MD) comprises a group of disorders involving mitochondrial dysfunction.
Takeshi Tokuyama, Asei Hirai, Isshin Shiiba, Naoki Ito, Keigo Matsuno, Keisuke Takeda, Kanata Saito, Koki Mii, Nobuko Matsushita, Toshifumi Fukuda, Ryoko Inatome, Shigeru Yanagi   +11 more
doaj   +1 more source

Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity

Frontiers in Bioscience-Landmark, 2022
Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China.
Jinling Wang, Xiufu Lin, Ningning Zhao, Guanping Dong, Wei Wu, Ke Huang, Junfen Fu   +6 more
doaj   +1 more source

Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. [PDF]

, 2015
Disrupting particular mitochondrial fission and fusion proteins leads to the death of specific neuronal populations; however, the normal functions of mitochondrial fission in neurons are poorly understood, especially in vivo, which limits the ...
Berthet, A, Diaz-Ramirez, LG, Gill, TM, Haddad, D, Kim, H, Lam, M, Mucke, L, Nakamura, K, Pathak, D, Ponnusamy, R, Sesaki, H, Shields, LY, Zhu, L   +12 more
core   +9 more sources

The Molecular Assembly State of Drp1 Controls its Association With the Mitochondrial Recruitment Receptors Mff and MIEF1/2

Frontiers in Cell and Developmental Biology, 2021
Drp1 is a central player in mitochondrial fission and is recruited to mitochondria by Mff and MIEFs (MIEF1 and MIEF2), but little is known about how its assembly state affects Drp1 mitochondrial recruitment and fission.
Rong Yu, Shao-Bo Jin, Maria Ankarcrona, Urban Lendahl, Urban Lendahl, Monica Nistér, Jian Zhao   +6 more
doaj   +1 more source

Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing

Biology Open, 2020
Mitochondria adapt to cellular needs by changes in morphology through fusion and fission events, referred to as mitochondrial dynamics. Mitochondrial function and morphology are intimately connected and the dysregulation of mitochondrial dynamics is ...
Susana Ponte, Lara Carvalho, Maria Gagliardi, Isabel Campos, Paulo J. Oliveira, António Jacinto   +5 more
doaj   +1 more source