Results 11 to 20 of about 29,512 (257)

A novel small molecule inhibitor of human Drp1

Scientific Reports, 2022
Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous pathophysiological processes.
Ayeshah A. Rosdah, Belinda M. Abbott, Christopher G. Langendorf, Yali Deng, Jia Q. Truong, Helen M. M. Waddell, Naomi X. Y. Ling, William J. Smiles, Lea M. D. Delbridge, Guei-Sheung Liu, Jonathan S. Oakhill, Shiang Y. Lim, Jessica K. Holien   +12 more
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MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff [PDF]

Scientific Reports, 2017
Mitochondrial dynamics is a fundamental cellular process and recruitment of Drp1 to mitochondria is an essential step in mitochondrial fission. Mff and MIEF1/2 (MiD51/49) serve as key receptors for recruitment of Drp1 to mitochondria in mammals. However,
Rong Yu, Tong Liu, Shao-Bo Jin, Chenfei Ning, Urban Lendahl, Monica Nistér, Jian Zhao   +6 more
doaj   +3 more sources

SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes [PDF]

Cell Reports, 2021
During somatic reprogramming, cellular energy metabolism fundamentally switches from predominantly mitochondrial oxidative phosphorylation toward glycolysis. This metabolic reprogramming, also called the Warburg effect, is critical for the induction of pluripotency, but its molecular mechanisms remain poorly defined.
Young Cha, Taewoo Kim, Jeha Jeon, Yongwoo Jang, Patrick B. Kim, Claudia Lopes, Pierre Leblanc, Bruce M. Cohen, Kwang-Soo Kim   +8 more
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Axotomy Induces Drp1-Dependent Fragmentation of Axonal Mitochondria [PDF]

Frontiers in Molecular Neuroscience, 2021
It is well established that CNS axons fail to regenerate, undergo retrograde dieback, and form dystrophic growth cones due to both intrinsic and extrinsic factors. We sought to investigate the role of axonal mitochondria in the axonal response to injury.
Joseph Kedra, Shen Lin, Almudena Pacheco, Gianluca Gallo, Gianluca Gallo, George M. Smith, George M. Smith   +6 more
openaire   +3 more sources

Drp1 phosphorylation and mitochondrial regulation [PDF]

EMBO reports, 2007
A paper by Cribbs & Strack (2007) in a recent issue of EMBO Reports , as well as an earlier study published by our group (Chang & Blackstone, 2007), emphasize the important roles of protein phosphorylation by cAMP‐dependent protein kinase (PKA) in the regulation of the dynamin‐related protein 1 (Drp1) GTPase and mitochondrial fission.
Chuang-Rung, Chang, Craig, Blackstone
openaire   +2 more sources

Parkin suppresses Drp1-independent mitochondrial division [PDF]

Biochemical and Biophysical Research Communications, 2016
The cycle of mitochondrial division and fusion disconnect and reconnect individual mitochondria in cells to remodel this energy-producing organelle. Although dynamin-related protein 1 (Drp1) plays a major role in mitochondrial division in cells, a reduced level of mitochondrial division still persists even in the absence of Drp1. It is unknown how much
Madhuparna, Roy, Kie, Itoh, Miho, Iijima, Hiromi, Sesaki   +3 more
openaire   +2 more sources

SUMO wrestling with Drp1 at mitochondria [PDF]

The EMBO Journal, 2013
EMBO J 32 11: 1514–1528; March222013; 10.1038/emboj.2013.65 Mitochondria undergo dynamic fission and fusion events, and disruptions in this balance can lead to cellular dysfunction or death. New work by Henley and colleagues identifies a key role for the SUMO protease SENP3 and its target Drp1, a key mediator of mitochondrial fission, in ischaemia.
Caroline A, Anderson, Craig, Blackstone
openaire   +2 more sources

DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries

PLOS ONE, 2021
Mitochondrial dynamics is a possible modulator of myocardial ischemia/reperfusion injuries (IRI). We previously reported that mice partially deficient in the fusion protein OPA1 exhibited higher IRI. Therefore, we investigated whether deficiency in the fission protein DRP1 encoded by Dnm1l gene would affect IRI in Dnm1l+/- mouse.
Bouche, Laura, Kamel, Rima, Tamareille, Sophie, Garcia, Gabriel, Villedieu, Camille, Pillot, Bruno, Gueguen, Naïg, Chehaitly, Ahmad, Chao de La Barca, Juan Manuel, Beaumont, Justine, Baetz, Delphine, Ovize, Michel, Sesaki, Hiromi, Henrion, Daniel, Reynier, Pascal, Lenaers, Guy, Prunier, Fabrice, Mirebeau-Prunier, Delphine   +17 more
openaire   +5 more sources

Bezafibrate Improves Mitochondrial Fission and Function in DNM1L-Deficient Patient Cells

Cells, 2020
Mitochondria are involved in many cellular processes and their main role is cellular energy production. They constantly undergo fission and fusion, and these counteracting processes are under strict balance. The cytosolic dynamin-related protein 1, Drp1,
Liza Douiev, Ruth Sheffer, Gabriella Horvath, Ann Saada   +3 more
doaj   +1 more source

Porcine Circovirus 2 Induction of ROS Is Responsible for Mitophagy in PK-15 Cells via Activation of Drp1 Phosphorylation

Viruses, 2020
Mitochondrial dynamics is essential for the maintenance of cell homeostasis. Previous studies have shown that porcine circovirus 2 (PCV2) infection decreases the mitochondrial membrane potential and causes the elevation of reactive oxygen species (ROS ...
Yikai Zhang, Renjie Sun, Xiaoliang Li, Weihuan Fang   +3 more
doaj   +1 more source