Results 31 to 40 of about 114,219 (358)
RNA Biology, 2022 RNA research and applications are underpinned by in vitro transcription (IVT), but RNA impurities resulting from the enzymatic reagents severely impede downstream applications. To improve the stability and purity of synthesized RNA, we have characterized
Heng Xia +6 more
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Base pair fluctuations in helical models for nucleic acids [PDF]
J. Chem. Phys. 154, 194102 (2021), 2021 A statistical method is developed to estimate the maximum amplitude of the base pair fluctuations in a three dimensional mesoscopic model for nucleic acids. The base pair thermal vibrations around the helix diameter are viewed as a Brownian motion for a particle embedded in a stable helical structure.
arxiv +1 more source
Scientific Reports, 2021 Insecticidal double-stranded RNAs (dsRNAs) silence expression of vital genes by activating the RNA interference (RNAi) mechanism in insect cells. Despite high commercial interest in insecticidal dsRNA, information on resistance to dsRNA is scarce ...
S. Mishra +17 more
semanticscholar +1 more source
Spool-nematic ordering of dsDNA and dsRNA under confinement [PDF]
Phys. Rev. Lett. 133, 148101 (2024), 2023 The ability of double-stranded DNA or RNA to locally melt and form kinks leads to strong non-linear elasticity effects that qualitatively affect their packing in confined spaces. Using analytical theory and numerical simulation we show that kink formation entails a mixed spool-nematic ordering of double-stranded DNA or RNA in spherical capsids ...
arxiv +1 more source
Next Generation dsRNA-Based Insect Control: Success So Far and Challenges
Frontiers in Plant Science, 2021 RNA interference (RNAi) is a method of gene silencing where dsRNA is digested into small interfering RNA (siRNA) in the presence of enzymes. These siRNAs then target homologous mRNA sequences aided by the RNA-induced silencing complex (RISC).
Rahul B. Nitnavare +5 more
semanticscholar +1 more source
Антибиотики и Химиотерапия, 2023 High variability of influenza viruses requires the development of agents for nonspecific resistance stimulation, along with the development of new drugs for prevention and treatment.
S. G. Gamaley +7 more
doaj +1 more source
Studying the effect of double-stranded RNA upon activity of mouse splenocytes using flow cytometry
Медицинская иммунология, 2023 Ribonucleic acids (RNA), in particular, double-stranded RNAs, due to their ability to modulate innate immune responses, are of undoubted interest in view of their usage as vaccine adjuvants.
E. S. Tsyplenkova +2 more
doaj +1 more source
RNAi-Mediated Management of Whitefly Bemisia tabaci by Oral Delivery of Double-stranded RNAs
Proceedings, 2019 The whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae) is a significant global pest of economically important vegetable, fibre, and ornamental crops. Whiteflies directly damage the plants by piercing and sucking essential nutrients, indirectly through ...
Ritesh G Jain +2 more
doaj +1 more source
Stimulating effect of double-stranded yeast RNA on the activity of interferon system genes
Медицинская иммунология, 2021 Influence of double-stranded RNA (dsRNA) from Saccharomyces cerevisiae yeast upon expression levels of the macrophage genes encoding TLR3 receptor, interferons alpha and beta (IFNα, IFNβ), 2’,5’-oligoadenylate synthetase (OAS) and protein kinase R (PKR ...
A. V. Bateneva +3 more
doaj +1 more source
European Journal of Entomology, 2017 RNA interference (RNAi) technology uses dsRNAs to silence specific targeted genes by downregulating their expression. It has become a potent tool for functional and regulatory studies of insect genes and has potential to be applied for insect control ...
Saikat Kumar B. GHOSH +1 more
doaj +1 more source