Results 31 to 40 of about 9,978 (230)
PLoS Genetics, 2017 Cytoplasmic assembly of ciliary dyneins, a process known as preassembly, requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated.
Ryosuke Yamamoto +12 more
doaj +1 more source
FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex.
PLoS Genetics, 2022 Assembly of dynein arms requires cytoplasmic processes which are mediated by dynein preassembly factors (DNAAFs). CFAP298, which is conserved in organisms with motile cilia, is required for assembly of dynein arms but with obscure mechanisms.
Limei Wang +3 more
doaj +1 more source
Nature Communications, 2017 Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disease resulting in reduced mucus clearance and impaired lung function. Here, the authors show that mutations in PIH1D3 are responsible for an X-linked form of PCD, affecting assembly of a ...
Chiara Olcese +47 more
doaj +1 more source
Manipulation of Host Microtubule Networks by Viral Microtubule-Associated Proteins
Viruses, 2022 Diverse DNA and RNA viruses utilize cytoskeletal networks to efficiently enter, replicate, and exit the host cell, while evading host immune responses. It is well established that the microtubule (MT) network is commonly hijacked by viruses to traffic to
Dahee Seo, Don B. Gammon
doaj +1 more source
Ciliobrevins as Tools for Studying Dynein Motor Function
Frontiers in Cellular Neuroscience, 2015 Dyneins are a small class of molecular motors that bind to microtubules and walk towards their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements.
Douglas eRoossien +2 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Dynein and intraflagellar transport [PDF]
Experimental Cell Research, 2015 Publisher Summary This chapter provides a brief background on intraflagellar transport (IFT) and reviews the studies culminating in the identification of the dynein motor that powers retrograde IFT. IFT is the active movement of multi-subunit particles along axonemal doublet microtubules in the space between the outer-doublet microtubules and the ...
Hou, Yuqing, Witman, George B.
openaire +3 more sources
Genetic analysis of the cytoplasmic dynein subunit families.
PLoS Genetics, 2006 Cytoplasmic dyneins, the principal microtubule minus-end-directed motor proteins of the cell, are involved in many essential cellular processes. The major form of this enzyme is a complex of at least six protein subunits, and in mammals all but one of ...
K Kevin Pfister +7 more
doaj +2 more sources
Scientific Reports, 2021 Cilia are protrusions of the cell surface and composed of hundreds of proteins many of which are evolutionary and functionally well conserved. In cells assembling motile cilia the expression of numerous ciliary components is under the control of the ...
Anja Beckers +14 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source