Clumping Morphology Influences Virulence Uncoupled from Echinocandin Resistance in Candida glabrata [PDF]
Microbiology Spectrum, 2022 Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host ...
Chenlin Hu +4 more
doaj +5 more sources
Molecular characterization of Echinocandin resistance and the CHS3-mediated adaptive response in Candida glabrata bloodstream infections in Eastern China [PDF]
BMC MicrobiologyBackground Candidemia caused by Candida glabrata is a serious fungal infection, and rising echinocandin resistance presents a significant clinical challenge.
Peishan Cong +7 more
doaj +2 more sources
Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? [PDF]
mBioEchinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus +13 more
doaj +2 more sources
More than flipping the lid: Cdc50 contributes to echinocandin resistance by regulating calcium homeostasis in Cryptococcus neoformans [PDF]
Microbial Cell, 2020 Echinocandins are the newest fungicidal drug class approved for clinical use against common invasive mycoses. Yet, they are ineffective against cryptococcosis, predominantly caused by Cryptococcus neoformans.
Chengjun Cao, Chaoyang Xue
doaj +2 more sources
Emergence of invasive candidiasis with multiple Candida species exhibiting azole and echinocandin resistance [PDF]
Frontiers in MicrobiologyBackgroundInvasive candidiasis (IC) is an increasingly common, expensive, and potentially fatal infection. However, IC caused by multiple Candida species is rarely reported in China.
Si-Jia Huang +9 more
doaj +2 more sources
A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in
mBio, 2019 Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao +4 more
doaj +2 more sources
KAJIAN MOLEKULER RESISTENSI Candida albicans TERHADAP ANTIFUNGI [PDF]
Jurnal Farmasi Sains dan Komunitas, 2014 : Candida albicans is one of the species Candida which mostly cause infection in human. Antifungal agent azole, polyene, echinocandin, and flucytosine are commonly used for Candida albicans infection treatment.
Damiana Sapta Candrasari
doaj +5 more sources
Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-
mBio, 2019 Aspergillus fumigatus is a leading cause of invasive fungal infections. Resistance to first-line triazole antifungals has led to therapy with echinocandin drugs. Recently, we identified several high-minimum-effective-concentration (MEC) A.
Shruthi Satish +10 more
doaj +2 more sources
Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. [PDF]
PLoS Pathogens, 2012 The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line therapeutics for ...
Sheena D Singh-Babak +9 more
doaj +1 more source
mBio, 2021 Fungal infections cause significant mortality and morbidity worldwide, and the limited existing antifungal reservoir is further weakened by the emergence of strains resistant to echinocandins, a first line of antifungal therapy.
Rocio Garcia-Rubio +5 more
doaj +1 more source